| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BACE1 | LIPT1 | ENSP00000318585 | ENSP00000377115 | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase; Belongs to the peptidase A1 family | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes; Belongs to the LplA family | 0.522 |
| BACE1 | TSGA10 | ENSP00000318585 | ENSP00000377123 | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase; Belongs to the peptidase A1 family | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.628 |
| CINP | TSGA10 | ENSP00000216756 | ENSP00000377123 | Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling; Belongs to the CINP family | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.552 |
| FBXO39 | ODF4 | ENSP00000321386 | ENSP00000331086 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton | 0.723 |
| FBXO39 | SPATA19 | ENSP00000321386 | ENSP00000299140 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis | 0.697 |
| FBXO39 | TSGA10 | ENSP00000321386 | ENSP00000377123 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.706 |
| LIPT1 | BACE1 | ENSP00000377115 | ENSP00000318585 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes; Belongs to the LplA family | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase; Belongs to the peptidase A1 family | 0.522 |
| LIPT1 | TSGA10 | ENSP00000377115 | ENSP00000377123 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes; Belongs to the LplA family | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.561 |
| ODF4 | FBXO39 | ENSP00000331086 | ENSP00000321386 | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.723 |
| ODF4 | SPATA19 | ENSP00000331086 | ENSP00000299140 | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis | 0.687 |
| ODF4 | TSGA10 | ENSP00000331086 | ENSP00000377123 | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.687 |
| PPP1R32 | TSGA10 | ENSP00000344140 | ENSP00000377123 | Protein phosphatase 1 regulatory subunit 32 | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.589 |
| ROPN1L | SPATA19 | ENSP00000421405 | ENSP00000299140 | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis | 0.465 |
| ROPN1L | TSGA10 | ENSP00000421405 | ENSP00000377123 | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.553 |
| SOX30 | TSGA10 | ENSP00000265007 | ENSP00000377123 | Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5’- ACAAT-3’ and shows a preference for guanine residues surrounding this core motif; SRY-boxes | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.650 |
| SPATA19 | FBXO39 | ENSP00000299140 | ENSP00000321386 | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.697 |
| SPATA19 | ODF4 | ENSP00000299140 | ENSP00000331086 | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton | 0.687 |
| SPATA19 | ROPN1L | ENSP00000299140 | ENSP00000421405 | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation | 0.465 |
| SPATA19 | TSGA10 | ENSP00000299140 | ENSP00000377123 | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | 0.610 |
| TSGA10 | BACE1 | ENSP00000377123 | ENSP00000318585 | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase; Belongs to the peptidase A1 family | 0.628 |
