node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASZ1 | ZFP1 | ENSP00000366221 | ENSP00000377080 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.907 |
CIZ1 | ZFP1 | ENSP00000439244 | ENSP00000377080 | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.568 |
DOT1L | MYC | ENSP00000381657 | ENSP00000479618 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA; Lysine methyltransferases | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’- CAC[GA]TG-3’. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis; Basic helix-loop-helix proteins | 0.441 |
DOT1L | PRDM2 | ENSP00000381657 | ENSP00000235372 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA; Lysine methyltransferases | PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates ’Lys-9’ of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.455 |
DOT1L | ZFP1 | ENSP00000381657 | ENSP00000377080 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA; Lysine methyltransferases | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.511 |
GATM | ZFP1 | ENSP00000379895 | ENSP00000377080 | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis; Belongs to the amidinotransferase family | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.518 |
KLHDC10 | ZFP1 | ENSP00000334140 | ENSP00000377080 | Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.549 |
MYC | DOT1L | ENSP00000479618 | ENSP00000381657 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’- CAC[GA]TG-3’. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis; Basic helix-loop-helix proteins | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA; Lysine methyltransferases | 0.441 |
MYC | TRIM28 | ENSP00000479618 | ENSP00000253024 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’- CAC[GA]TG-3’. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis; Basic helix-loop-helix proteins | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.487 |
MYC | ZFP1 | ENSP00000479618 | ENSP00000377080 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’- CAC[GA]TG-3’. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis; Basic helix-loop-helix proteins | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.501 |
PRDM2 | DOT1L | ENSP00000235372 | ENSP00000381657 | PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates ’Lys-9’ of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene; Belongs to the class V-like SAM-binding methyltransferase superfamily | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA; Lysine methyltransferases | 0.455 |
PRDM2 | ZFP1 | ENSP00000235372 | ENSP00000377080 | PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates ’Lys-9’ of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene; Belongs to the class V-like SAM-binding methyltransferase superfamily | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.478 |
SPRR1B | ZFP1 | ENSP00000306461 | ENSP00000377080 | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage; Belongs to the cornifin (SPRR) family | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.468 |
TRIM28 | MYC | ENSP00000253024 | ENSP00000479618 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’- CAC[GA]TG-3’. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis; Basic helix-loop-helix proteins | 0.487 |
TRIM28 | ZFP1 | ENSP00000253024 | ENSP00000377080 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.918 |
ZFP1 | CASZ1 | ENSP00000377080 | ENSP00000366221 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type | 0.907 |
ZFP1 | CIZ1 | ENSP00000377080 | ENSP00000439244 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1 | 0.568 |
ZFP1 | DOT1L | ENSP00000377080 | ENSP00000381657 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates ’Lys-79’ of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA; Lysine methyltransferases | 0.511 |
ZFP1 | GATM | ENSP00000377080 | ENSP00000379895 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis; Belongs to the amidinotransferase family | 0.518 |
ZFP1 | KLHDC10 | ENSP00000377080 | ENSP00000334140 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 | 0.549 |