| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DGUOK | FAM13B | ENSP00000264093 | ENSP00000033079 | Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | 0.496 |
| DGUOK | NME5 | ENSP00000264093 | ENSP00000265191 | Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | 0.405 |
| DGUOK | RASGEF1C | ENSP00000264093 | ENSP00000377037 | Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) | 0.477 |
| FAM13B | DGUOK | ENSP00000033079 | ENSP00000264093 | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents | 0.496 |
| FAM13B | HNRNPAB | ENSP00000033079 | ENSP00000351108 | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site; RNA binding motif containing | 0.583 |
| FAM13B | NME5 | ENSP00000033079 | ENSP00000265191 | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | 0.580 |
| FAM13B | RASGEF1C | ENSP00000033079 | ENSP00000377037 | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) | 0.661 |
| FAM13B | RUFY1 | ENSP00000033079 | ENSP00000325594 | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | 0.552 |
| FAM13B | WNT8A | ENSP00000033079 | ENSP00000426653 | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.474 |
| HNRNPAB | FAM13B | ENSP00000351108 | ENSP00000033079 | Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site; RNA binding motif containing | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | 0.583 |
| HNRNPAB | NME5 | ENSP00000351108 | ENSP00000265191 | Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site; RNA binding motif containing | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | 0.474 |
| HNRNPAB | RASGEF1C | ENSP00000351108 | ENSP00000377037 | Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site; RNA binding motif containing | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) | 0.550 |
| HNRNPAB | RUFY1 | ENSP00000351108 | ENSP00000325594 | Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site; RNA binding motif containing | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | 0.458 |
| NME5 | DGUOK | ENSP00000265191 | ENSP00000264093 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents | 0.405 |
| NME5 | FAM13B | ENSP00000265191 | ENSP00000033079 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins | 0.580 |
| NME5 | HNRNPAB | ENSP00000265191 | ENSP00000351108 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site; RNA binding motif containing | 0.474 |
| NME5 | RASGEF1C | ENSP00000265191 | ENSP00000377037 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) | 0.594 |
| NME5 | RUFY1 | ENSP00000265191 | ENSP00000325594 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | 0.494 |
| NME5 | WNT8A | ENSP00000265191 | ENSP00000426653 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity); NME/NM23 family | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.501 |
| PHYHIPL | PSD2 | ENSP00000362987 | ENSP00000274710 | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system; Fibronectin type III domain containing | Pleckstrin and Sec7 domain containing 2 | 0.544 |
