| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP11C | CYB561 | ENSP00000332756 | ENSP00000376702 | Phospholipid-transporting ATPase IG; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cho [...] | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | 0.458 |
| CYB561 | ATP11C | ENSP00000376702 | ENSP00000332756 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Phospholipid-transporting ATPase IG; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cho [...] | 0.458 |
| CYB561 | CYB5R2 | ENSP00000376702 | ENSP00000437041 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | NADH-cytochrome b5 reductase 2; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1); Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | 0.475 |
| CYB561 | DBH | ENSP00000376702 | ENSP00000376776 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline | 0.656 |
| CYB561 | DOPEY2 | ENSP00000376702 | ENSP00000382104 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | 0.567 |
| CYB561 | FADS6 | ENSP00000376702 | ENSP00000481684 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Fatty acid desaturase 6; Belongs to the fatty acid desaturase type 1 family | 0.545 |
| CYB561 | FRRS1 | ENSP00000376702 | ENSP00000287474 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family | 0.931 |
| CYB561 | JOSD2 | ENSP00000376702 | ENSP00000468956 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Josephin-2; Cleaves ’Lys-63’-linked poly-ubiquitin chains, and with lesser efficiency ’Lys-48’-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme; MJD deubiquinating enzymes | 0.685 |
| CYB561 | MLF1 | ENSP00000376702 | ENSP00000376568 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus; Belongs to the MLF family | 0.576 |
| CYB561 | PAM | ENSP00000376702 | ENSP00000306100 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | Peptidyl-glycine alpha-amidating monooxygenase; Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity | 0.800 |
| CYB561 | SMOC1 | ENSP00000376702 | ENSP00000355110 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | SPARC-related modular calcium-binding protein 1; Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation; SPARC family | 0.501 |
| CYB5R2 | CYB561 | ENSP00000437041 | ENSP00000376702 | NADH-cytochrome b5 reductase 2; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1); Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | 0.475 |
| CYB5R2 | DOPEY2 | ENSP00000437041 | ENSP00000382104 | NADH-cytochrome b5 reductase 2; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1); Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | 0.407 |
| DBH | CYB561 | ENSP00000376776 | ENSP00000376702 | Dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | 0.656 |
| DOPEY2 | CYB561 | ENSP00000382104 | ENSP00000376702 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | 0.567 |
| DOPEY2 | CYB5R2 | ENSP00000382104 | ENSP00000437041 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | NADH-cytochrome b5 reductase 2; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1); Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family | 0.407 |
| FADS6 | CYB561 | ENSP00000481684 | ENSP00000376702 | Fatty acid desaturase 6; Belongs to the fatty acid desaturase type 1 family | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | 0.545 |
| FRRS1 | CYB561 | ENSP00000287474 | ENSP00000376702 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | 0.931 |
| JOSD2 | CYB561 | ENSP00000468956 | ENSP00000376702 | Josephin-2; Cleaves ’Lys-63’-linked poly-ubiquitin chains, and with lesser efficiency ’Lys-48’-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme; MJD deubiquinating enzymes | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 | 0.685 |
| JOSD2 | MLF1 | ENSP00000468956 | ENSP00000376568 | Josephin-2; Cleaves ’Lys-63’-linked poly-ubiquitin chains, and with lesser efficiency ’Lys-48’-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme; MJD deubiquinating enzymes | Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus; Belongs to the MLF family | 0.500 |
