node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FLT1 | NT5DC3 | ENSP00000282397 | ENSP00000376615 | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferati [...] | 5’-nucleotidase domain containing 3 | 0.620 |
GABRR3 | MINA | ENSP00000481321 | ENSP00000328251 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated ’Lys-9’ on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on ’His-39’. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily | 0.634 |
GABRR3 | NT5DC3 | ENSP00000481321 | ENSP00000376615 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 5’-nucleotidase domain containing 3 | 0.630 |
GGN | NT5DC3 | ENSP00000334940 | ENSP00000376615 | Gametogenetin; May be involved in spermatogenesis | 5’-nucleotidase domain containing 3 | 0.555 |
GNPTAB | NT5DC3 | ENSP00000299314 | ENSP00000376615 | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment; EF-hand domain containing | 5’-nucleotidase domain containing 3 | 0.594 |
HCFC2 | NT5DC3 | ENSP00000229330 | ENSP00000376615 | Host cell factor C2 | 5’-nucleotidase domain containing 3 | 0.774 |
HCFC2 | SYN3 | ENSP00000229330 | ENSP00000351614 | Host cell factor C2 | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins | 0.642 |
HSPB3 | NT5DC3 | ENSP00000303394 | ENSP00000376615 | Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins | 5’-nucleotidase domain containing 3 | 0.634 |
MINA | GABRR3 | ENSP00000328251 | ENSP00000481321 | Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated ’Lys-9’ on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on ’His-39’. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.634 |
MINA | NT5DC3 | ENSP00000328251 | ENSP00000376615 | Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated ’Lys-9’ on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on ’His-39’. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily | 5’-nucleotidase domain containing 3 | 0.645 |
NT5DC3 | FLT1 | ENSP00000376615 | ENSP00000282397 | 5’-nucleotidase domain containing 3 | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferati [...] | 0.620 |
NT5DC3 | GABRR3 | ENSP00000376615 | ENSP00000481321 | 5’-nucleotidase domain containing 3 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits | 0.630 |
NT5DC3 | GGN | ENSP00000376615 | ENSP00000334940 | 5’-nucleotidase domain containing 3 | Gametogenetin; May be involved in spermatogenesis | 0.555 |
NT5DC3 | GNPTAB | ENSP00000376615 | ENSP00000299314 | 5’-nucleotidase domain containing 3 | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment; EF-hand domain containing | 0.594 |
NT5DC3 | HCFC2 | ENSP00000376615 | ENSP00000229330 | 5’-nucleotidase domain containing 3 | Host cell factor C2 | 0.774 |
NT5DC3 | HSPB3 | ENSP00000376615 | ENSP00000303394 | 5’-nucleotidase domain containing 3 | Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins | 0.634 |
NT5DC3 | MINA | ENSP00000376615 | ENSP00000328251 | 5’-nucleotidase domain containing 3 | Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated ’Lys-9’ on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on ’His-39’. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily | 0.645 |
NT5DC3 | SYN3 | ENSP00000376615 | ENSP00000351614 | 5’-nucleotidase domain containing 3 | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins | 0.600 |
NT5DC3 | TNN | ENSP00000376615 | ENSP00000239462 | 5’-nucleotidase domain containing 3 | Tenascin-N; Extracellular matrix protein that seems to be a ligand for ITGA8-ITGB1, ITGAV-ITGB1 and ITGA4-ITGB1 (By similarity). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells; Belon [...] | 0.733 |
NT5DC3 | ZKSCAN7 | ENSP00000376615 | ENSP00000273320 | 5’-nucleotidase domain containing 3 | Zinc finger protein with KRAB and SCAN domains 7; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.669 |