• Version:
  • 11.0 [archived version]
STRINGSTRING
ARMC1 ARMC1 C6orf203 C6orf203 NEK11 NEK11 CFDP1 CFDP1 ARMC2 ARMC2 RHOBTB3 RHOBTB3 C10orf11 C10orf11 SPATA9 SPATA9 FAM13A FAM13A CCDC38 CCDC38 ZKSCAN3 ZKSCAN3
"ARMC2" - Armadillo repeat containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARMC2Armadillo repeat containing 2 (867 aa)    
Predicted Functional Partners:
ARMC1
Armadillo repeat containing 1 (282 aa)
           
  0.709
CCDC38
Coiled-coil domain containing 38 (563 aa)
           
  0.706
SPATA9
Spermatogenesis-associated protein 9; May play a role in testicular development/spermatogenesis and may be an important factor in male infertility (254 aa)
     
   
  0.690
ZKSCAN3
Zinc finger protein with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5’-[GT][AG][AGT]GGGG-3’ and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas; SCAN domain containing (538 aa)
       
 
  0.574
C10orf11
Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation (198 aa)
       
 
  0.564
NEK11
Serine/threonine-protein kinase Nek11; Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation (645 aa)
     
   
  0.555
CFDP1
Craniofacial development protein 1; May play a role during embryogenesis (299 aa)
           
  0.538
RHOBTB3
Rho-related BTB domain-containing protein 3; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9; BTB domain containing (611 aa)
       
 
  0.522
FAM13A
Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family (1023 aa)
           
  0.520
C6orf203
Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203 (240 aa)
           
  0.518
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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