node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPN13 | CD300E | ENSP00000295055 | ENSP00000376395 | Calpain-13; Probable non-lysosomal thiol-protease; Calpains | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | 0.461 |
CAPN13 | CHST4 | ENSP00000295055 | ENSP00000341206 | Calpain-13; Probable non-lysosomal thiol-protease; Calpains | Carbohydrate sulfotransferase 4; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recogni [...] | 0.465 |
CD247 | CD300E | ENSP00000354782 | ENSP00000376395 | T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of do [...] | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | 0.565 |
CD247 | TYROBP | ENSP00000354782 | ENSP00000262629 | T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of do [...] | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.649 |
CD300E | CAPN13 | ENSP00000376395 | ENSP00000295055 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | Calpain-13; Probable non-lysosomal thiol-protease; Calpains | 0.461 |
CD300E | CD247 | ENSP00000376395 | ENSP00000354782 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of do [...] | 0.565 |
CD300E | CHST4 | ENSP00000376395 | ENSP00000341206 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | Carbohydrate sulfotransferase 4; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recogni [...] | 0.525 |
CD300E | FCER1G | ENSP00000376395 | ENSP00000289902 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | 0.648 |
CD300E | LILRA1 | ENSP00000376395 | ENSP00000251372 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors | 0.503 |
CD300E | LILRA5 | ENSP00000376395 | ENSP00000404236 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | Leukocyte immunoglobulin-like receptor subfamily A member 5; May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition; Activating leukocyte immunoglobulin like receptors | 0.449 |
CD300E | MNDA | ENSP00000376395 | ENSP00000357123 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | Myeloid cell nuclear differentiation antigen; May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1; Pyrin and HIN domain family | 0.417 |
CD300E | RAB3B | ENSP00000376395 | ENSP00000360718 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | Ras-related protein Rab-3B; Protein transport. Probably involved in vesicular traffic (By similarity); RAB, member RAS oncogene GTPases | 0.414 |
CD300E | TREM1 | ENSP00000376395 | ENSP00000244709 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock; CD molecules | 0.429 |
CD300E | TYROBP | ENSP00000376395 | ENSP00000262629 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.994 |
CHST4 | CAPN13 | ENSP00000341206 | ENSP00000295055 | Carbohydrate sulfotransferase 4; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recogni [...] | Calpain-13; Probable non-lysosomal thiol-protease; Calpains | 0.465 |
CHST4 | CD300E | ENSP00000341206 | ENSP00000376395 | Carbohydrate sulfotransferase 4; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recogni [...] | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | 0.525 |
FCER1G | CD300E | ENSP00000289902 | ENSP00000376395 | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | 0.648 |
FCER1G | MNDA | ENSP00000289902 | ENSP00000357123 | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | Myeloid cell nuclear differentiation antigen; May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1; Pyrin and HIN domain family | 0.598 |
FCER1G | TYROBP | ENSP00000289902 | ENSP00000262629 | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin; Belongs to the CD3Z/FCER1G family | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.960 |
LILRA1 | CD300E | ENSP00000251372 | ENSP00000376395 | Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules | 0.503 |