GPR123 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GPR123

Adhesion G protein-coupled receptor A1; Orphan receptor (560 aa)

Predicted Functional Partners:

SCTR

0.800

GPR114

0.795

KNDC1

0.770

LPHN1

0.756

LPHN2

0.752

LPHN3

0.741

GPR128

0.730

GPR97

0.724

GPR113

0.723

GPR144

0.705

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GPR113	GPR123	ENSP00000307831	ENSP00000376384	Adhesion G-protein coupled receptor F3; Orphan receptor	Adhesion G protein-coupled receptor A1; Orphan receptor	0.723
GPR114	GPR123	ENSP00000342981	ENSP00000376384	Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide- binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking)	Adhesion G protein-coupled receptor A1; Orphan receptor	0.795
GPR123	GPR113	ENSP00000376384	ENSP00000307831	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G-protein coupled receptor F3; Orphan receptor	0.723
GPR123	GPR114	ENSP00000376384	ENSP00000342981	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide- binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking)	0.795
GPR123	GPR128	ENSP00000376384	ENSP00000273352	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G-protein coupled receptor G7; Orphan receptor	0.730
GPR123	GPR144	ENSP00000376384	ENSP00000335156	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G-protein coupled receptor D2; Orphan receptor	0.705
GPR123	GPR97	ENSP00000376384	ENSP00000332900	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins	0.724
GPR123	KNDC1	ENSP00000376384	ENSP00000304437	Adhesion G protein-coupled receptor A1; Orphan receptor	Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence	0.770
GPR123	LPHN1	ENSP00000376384	ENSP00000340688	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	0.756
GPR123	LPHN2	ENSP00000376384	ENSP00000322270	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	0.752
GPR123	LPHN3	ENSP00000376384	ENSP00000422533	Adhesion G protein-coupled receptor A1; Orphan receptor	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	0.741
GPR123	SCTR	ENSP00000376384	ENSP00000019103	Adhesion G protein-coupled receptor A1; Orphan receptor	Secretin receptor; This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Glucagon receptor family	0.800
GPR128	GPR123	ENSP00000273352	ENSP00000376384	Adhesion G-protein coupled receptor G7; Orphan receptor	Adhesion G protein-coupled receptor A1; Orphan receptor	0.730
GPR144	GPR123	ENSP00000335156	ENSP00000376384	Adhesion G-protein coupled receptor D2; Orphan receptor	Adhesion G protein-coupled receptor A1; Orphan receptor	0.705
GPR97	GPR123	ENSP00000332900	ENSP00000376384	Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By similarity). Seems to signal through G-alpha(q)-proteins	Adhesion G protein-coupled receptor A1; Orphan receptor	0.724
KNDC1	GPR123	ENSP00000304437	ENSP00000376384	Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence	Adhesion G protein-coupled receptor A1; Orphan receptor	0.770
LPHN1	GPR123	ENSP00000340688	ENSP00000376384	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	Adhesion G protein-coupled receptor A1; Orphan receptor	0.756
LPHN2	GPR123	ENSP00000322270	ENSP00000376384	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Adhesion G protein-coupled receptor A1; Orphan receptor	0.752
LPHN3	GPR123	ENSP00000422533	ENSP00000376384	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	Adhesion G protein-coupled receptor A1; Orphan receptor	0.741
SCTR	GPR123	ENSP00000019103	ENSP00000376384	Secretin receptor; This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Glucagon receptor family	Adhesion G protein-coupled receptor A1; Orphan receptor	0.800

Network

Fusion

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Neighborhood

© STRING Consortium 2020

Credits

Access

Info

About