CRYGS protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Predicted Interactions

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Score

CRYGS

Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family (178 aa)

Predicted Functional Partners:

CRYAB

0.842

HSPB4

0.838

CRYA1

0.838

BFSP2

0.795

GJA3

0.772

BFSP1

0.740

GJA8

0.737

LIM2

0.727

MIP

0.706

CHMP4B

0.687

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFSP1	BFSP2	ENSP00000367104	ENSP00000304987	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	0.968
BFSP1	CHMP4B	ENSP00000367104	ENSP00000217402	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...]	0.728
BFSP1	CRYA1	ENSP00000367104	ENSP00000482816	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.767
BFSP1	CRYAB	ENSP00000367104	ENSP00000433560	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.699
BFSP1	CRYGS	ENSP00000367104	ENSP00000376287	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.740
BFSP1	GJA3	ENSP00000367104	ENSP00000241125	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.725
BFSP1	GJA8	ENSP00000367104	ENSP00000358238	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.723
BFSP1	HSPB4	ENSP00000367104	ENSP00000291554	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.768
BFSP1	LIM2	ENSP00000367104	ENSP00000221973	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Lens intrinsic membrane protein 2	0.740
BFSP1	MIP	ENSP00000367104	ENSP00000257979	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.887
BFSP2	BFSP1	ENSP00000304987	ENSP00000367104	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family	0.968
BFSP2	CHMP4B	ENSP00000304987	ENSP00000217402	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...]	0.714
BFSP2	CRYA1	ENSP00000304987	ENSP00000482816	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	CRYAB	ENSP00000304987	ENSP00000433560	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.708
BFSP2	CRYGS	ENSP00000304987	ENSP00000376287	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.795
BFSP2	GJA3	ENSP00000304987	ENSP00000241125	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.835
BFSP2	GJA8	ENSP00000304987	ENSP00000358238	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.762
BFSP2	HSPB4	ENSP00000304987	ENSP00000291554	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	LIM2	ENSP00000304987	ENSP00000221973	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Lens intrinsic membrane protein 2	0.740
BFSP2	MIP	ENSP00000304987	ENSP00000257979	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.814

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