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STRINGSTRING
BFSP2 BFSP2 GRIFIN GRIFIN BFSP1 BFSP1 MSRA MSRA CRYGN CRYGN SP1 SP1 SULT2B1 SULT2B1 LENEP LENEP OR6K3 OR6K3 SPATA45 SPATA45 SH3BP5L SH3BP5L
"LENEP" - Lens epithelial cell protein LEP503 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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LENEPLens epithelial cell protein LEP503; May play a role in lens epithelial cell differentiation (61 aa)    
Predicted Functional Partners:
SP1
Transcription factor Sp1; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] (785 aa)
            
  0.629
SPATA45
Spermatogenesis-associated protein 45; Spermatogenesis associated 45; Belongs to the SPATA45 family (98 aa)
            
  0.533
SULT2B1
Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...] (365 aa)
            
  0.533
OR6K3
Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6 (315 aa)
            
  0.511
MSRA
Mitochondrial peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (235 aa)
            
  0.494
BFSP1
Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family (665 aa)
            
  0.477
GRIFIN
Grifin; Galectin-related inter-fiber protein (144 aa)
            
  0.477
BFSP2
Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family (415 aa)
            
  0.473
CRYGN
Beta-gamma crystallins (182 aa)
            
  0.456
SH3BP5L
SH3 binding domain protein 5 like (393 aa)
            
  0.446
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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