MB21D2 protein (human) - STRING database

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MB21D2

Protein MB21D2; Mab-21 domain containing 2 (491 aa)

Predicted Functional Partners:

FAM46D

0.729

MIEF1

0.723

MAB21L3

0.718

TAMM41

0.674

ITPRIPL2

0.673

PAPOLG

0.660

STRBP

0.636

NOL6

0.629

MIEF2

0.628

MB21D1

0.601

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM46D	ITPRIPL2	ENSP00000443410	ENSP00000370849	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	0.639
FAM46D	MAB21L3	ENSP00000443410	ENSP00000358512	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Protein mab-21-like 3; Mab-21 like 3	0.691
FAM46D	MB21D1	ENSP00000443410	ENSP00000359339	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Cyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2’,5’ phosphodiester linkage at the GpA step and the formation of a 3’,5’ phosphodiester linkage at the ApG step, producing c[G(2’,5’)pA(3’,5’)p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TME [...]	0.497
FAM46D	MB21D2	ENSP00000443410	ENSP00000376246	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Protein MB21D2; Mab-21 domain containing 2	0.729
FAM46D	MIEF1	ENSP00000443410	ENSP00000327124	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Mitochondrial dynamics protein MID51; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assem [...]	0.631
FAM46D	MIEF2	ENSP00000443410	ENSP00000379057	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Mitochondrial dynamics protein MID49; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity	0.633
FAM46D	NOL6	ENSP00000443410	ENSP00000297990	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Nucleolar protein 6; Belongs to the NRAP family	0.627
FAM46D	PAPOLG	ENSP00000443410	ENSP00000238714	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3’-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA	0.650
FAM46D	STRBP	ENSP00000443410	ENSP00000415968	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Spermatid perinuclear RNA-binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity)	0.570
FAM46D	TAMM41	ENSP00000443410	ENSP00000398596	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity); Belongs to the TAM41 family	0.678
ITPRIPL2	FAM46D	ENSP00000370849	ENSP00000443410	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.639
ITPRIPL2	MAB21L3	ENSP00000370849	ENSP00000358512	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Protein mab-21-like 3; Mab-21 like 3	0.550
ITPRIPL2	MB21D2	ENSP00000370849	ENSP00000376246	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Protein MB21D2; Mab-21 domain containing 2	0.673
ITPRIPL2	MIEF1	ENSP00000370849	ENSP00000327124	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Mitochondrial dynamics protein MID51; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assem [...]	0.658
ITPRIPL2	MIEF2	ENSP00000370849	ENSP00000379057	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Mitochondrial dynamics protein MID49; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity	0.662
ITPRIPL2	NOL6	ENSP00000370849	ENSP00000297990	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Nucleolar protein 6; Belongs to the NRAP family	0.584
ITPRIPL2	PAPOLG	ENSP00000370849	ENSP00000238714	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3’-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA	0.585
ITPRIPL2	STRBP	ENSP00000370849	ENSP00000415968	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Spermatid perinuclear RNA-binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity)	0.585
ITPRIPL2	TAMM41	ENSP00000370849	ENSP00000398596	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity); Belongs to the TAM41 family	0.618
MAB21L3	FAM46D	ENSP00000358512	ENSP00000443410	Protein mab-21-like 3; Mab-21 like 3	Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.691

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