| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AJAP1 | ZNF493 | ENSP00000367433 | ENSP00000376110 | Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.474 |
| CDK12 | ZNF493 | ENSP00000398880 | ENSP00000376110 | Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates ’Ser-5’ in CTD repeats that are already phosphorylated at ’Ser-7’, but can also phosphorylate ’Ser-2’. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leadin [...] | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.407 |
| CENPH | ZNF493 | ENSP00000283006 | ENSP00000376110 | Centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.795 |
| GALNT7 | ZNF493 | ENSP00000265000 | ENSP00000376110 | N-acetylgalactosaminyltransferase 7; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide su [...] | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
| LMO3 | ZNF493 | ENSP00000442786 | ENSP00000376110 | LIM domain only protein 3; LIM domain containing | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.466 |
| PIEZO1 | ZNF493 | ENSP00000301015 | ENSP00000376110 | Piezo-type mechanosensitive ion channel component 1; Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor th [...] | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.443 |
| SLC19A1 | ZNF493 | ENSP00000308895 | ENSP00000376110 | Folate transporter 1; Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump; Minor histocompatibility antigens | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.405 |
| SLC43A3 | ZNF493 | ENSP00000434515 | ENSP00000376110 | Solute carrier family 43 member 3; Putative transporter; Belongs to the SLC43A transporter (TC 2.A.1.44) family | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.559 |
| TRIM28 | ZNF493 | ENSP00000253024 | ENSP00000376110 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.917 |
| ZNF493 | AJAP1 | ENSP00000376110 | ENSP00000367433 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration | 0.474 |
| ZNF493 | CDK12 | ENSP00000376110 | ENSP00000398880 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates ’Ser-5’ in CTD repeats that are already phosphorylated at ’Ser-7’, but can also phosphorylate ’Ser-2’. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leadin [...] | 0.407 |
| ZNF493 | CENPH | ENSP00000376110 | ENSP00000283006 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate | 0.795 |
| ZNF493 | GALNT7 | ENSP00000376110 | ENSP00000265000 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | N-acetylgalactosaminyltransferase 7; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide su [...] | 0.440 |
| ZNF493 | LMO3 | ENSP00000376110 | ENSP00000442786 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | LIM domain only protein 3; LIM domain containing | 0.466 |
| ZNF493 | PIEZO1 | ENSP00000376110 | ENSP00000301015 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Piezo-type mechanosensitive ion channel component 1; Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor th [...] | 0.443 |
| ZNF493 | SLC19A1 | ENSP00000376110 | ENSP00000308895 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Folate transporter 1; Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump; Minor histocompatibility antigens | 0.405 |
| ZNF493 | SLC43A3 | ENSP00000376110 | ENSP00000434515 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Solute carrier family 43 member 3; Putative transporter; Belongs to the SLC43A transporter (TC 2.A.1.44) family | 0.559 |
| ZNF493 | TRIM28 | ENSP00000376110 | ENSP00000253024 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.917 |
