node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP13A2 | C19orf12 | ENSP00000327214 | ENSP00000376103 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | Protein C19orf12; Chromosome 19 open reading frame 12 | 0.670 |
ATP13A2 | DCAF17 | ENSP00000327214 | ENSP00000364404 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.701 |
ATP13A2 | ENSG00000250232 | ENSP00000327214 | ENSP00000365536 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | PRA1 family protein; Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | 0.596 |
ATP13A2 | FA2H | ENSP00000327214 | ENSP00000219368 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | Fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids; Belongs to the sterol desaturase family. SCS7 subfamily | 0.697 |
ATP13A2 | PANK1 | ENSP00000327214 | ENSP00000302108 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | Pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration; Belongs to the type II pantothenate kinase family | 0.587 |
ATP13A2 | PANK2 | ENSP00000327214 | ENSP00000313377 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | Pantothenate kinase 2, mitochondrial; May be the master regulator of the CoA biosynthesis; Belongs to the type II pantothenate kinase family | 0.768 |
ATP13A2 | PLA2G6 | ENSP00000327214 | ENSP00000333142 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | 85/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods; Anky [...] | 0.749 |
ATP13A2 | WDR45 | ENSP00000327214 | ENSP00000348848 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | WD repeat domain phosphoinositide-interacting protein 4; Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation; Belongs to the WD repeat SVP1 family | 0.584 |
C19orf12 | ATP13A2 | ENSP00000376103 | ENSP00000327214 | Protein C19orf12; Chromosome 19 open reading frame 12 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | 0.670 |
C19orf12 | DCAF17 | ENSP00000376103 | ENSP00000364404 | Protein C19orf12; Chromosome 19 open reading frame 12 | DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.735 |
C19orf12 | ENSG00000250232 | ENSP00000376103 | ENSP00000365536 | Protein C19orf12; Chromosome 19 open reading frame 12 | PRA1 family protein; Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 | 0.765 |
C19orf12 | FA2H | ENSP00000376103 | ENSP00000219368 | Protein C19orf12; Chromosome 19 open reading frame 12 | Fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids; Belongs to the sterol desaturase family. SCS7 subfamily | 0.766 |
C19orf12 | FAM73A | ENSP00000376103 | ENSP00000393675 | Protein C19orf12; Chromosome 19 open reading frame 12 | Mitoguardin 1; Regulator of mitochondrial fusion- acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD; Belongs to the mitoguardin family | 0.658 |
C19orf12 | PANK1 | ENSP00000376103 | ENSP00000302108 | Protein C19orf12; Chromosome 19 open reading frame 12 | Pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration; Belongs to the type II pantothenate kinase family | 0.739 |
C19orf12 | PANK2 | ENSP00000376103 | ENSP00000313377 | Protein C19orf12; Chromosome 19 open reading frame 12 | Pantothenate kinase 2, mitochondrial; May be the master regulator of the CoA biosynthesis; Belongs to the type II pantothenate kinase family | 0.802 |
C19orf12 | PLA2G6 | ENSP00000376103 | ENSP00000333142 | Protein C19orf12; Chromosome 19 open reading frame 12 | 85/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods; Anky [...] | 0.730 |
C19orf12 | VSTM2B | ENSP00000376103 | ENSP00000335038 | Protein C19orf12; Chromosome 19 open reading frame 12 | V-set and transmembrane domain containing 2B | 0.697 |
C19orf12 | WDR45 | ENSP00000376103 | ENSP00000348848 | Protein C19orf12; Chromosome 19 open reading frame 12 | WD repeat domain phosphoinositide-interacting protein 4; Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation; Belongs to the WD repeat SVP1 family | 0.760 |
DCAF17 | ATP13A2 | ENSP00000364404 | ENSP00000327214 | DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance; ATPase orphan transporters | 0.701 |
DCAF17 | C19orf12 | ENSP00000364404 | ENSP00000376103 | DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | Protein C19orf12; Chromosome 19 open reading frame 12 | 0.735 |