| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASPHD1 | FAM117B | ENSP00000311447 | ENSP00000376071 | Aspartate beta-hydroxylase domain containing 1 | Protein FAM117B; Family with sequence similarity 117 member B | 0.546 |
| DPP3 | FAM117B | ENSP00000353701 | ENSP00000376071 | Dipeptidyl peptidase 3; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro); Belongs to the peptidase M49 family | Protein FAM117B; Family with sequence similarity 117 member B | 0.525 |
| DPP3 | MCMBP | ENSP00000353701 | ENSP00000353098 | Dipeptidyl peptidase 3; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro); Belongs to the peptidase M49 family | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion | 0.645 |
| DYRK1A | FAM117B | ENSP00000381932 | ENSP00000376071 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] | Protein FAM117B; Family with sequence similarity 117 member B | 0.564 |
| FAM117B | ASPHD1 | ENSP00000376071 | ENSP00000311447 | Protein FAM117B; Family with sequence similarity 117 member B | Aspartate beta-hydroxylase domain containing 1 | 0.546 |
| FAM117B | DPP3 | ENSP00000376071 | ENSP00000353701 | Protein FAM117B; Family with sequence similarity 117 member B | Dipeptidyl peptidase 3; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro); Belongs to the peptidase M49 family | 0.525 |
| FAM117B | DYRK1A | ENSP00000376071 | ENSP00000381932 | Protein FAM117B; Family with sequence similarity 117 member B | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in t [...] | 0.564 |
| FAM117B | KDM5B | ENSP00000376071 | ENSP00000356234 | Protein FAM117B; Family with sequence similarity 117 member B | Lysine-specific demethylase 5B; Histone demethylase that demethylates ’Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’ or H3 ’Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ’Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock [...] | 0.524 |
| FAM117B | MCMBP | ENSP00000376071 | ENSP00000353098 | Protein FAM117B; Family with sequence similarity 117 member B | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion | 0.622 |
| FAM117B | NRBP1 | ENSP00000376071 | ENSP00000233557 | Protein FAM117B; Family with sequence similarity 117 member B | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.795 |
| FAM117B | TSC22D2 | ENSP00000376071 | ENSP00000354543 | Protein FAM117B; Family with sequence similarity 117 member B | TSC22 domain family member 2 | 0.821 |
| FAM117B | TSC22D3 | ENSP00000376071 | ENSP00000361458 | Protein FAM117B; Family with sequence similarity 117 member B | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulat [...] | 0.804 |
| FAM117B | TSC22D4 | ENSP00000376071 | ENSP00000300181 | Protein FAM117B; Family with sequence similarity 117 member B | TSC22 domain family protein 4; Transcriptional repressor | 0.712 |
| FAM117B | WDR1 | ENSP00000376071 | ENSP00000427687 | Protein FAM117B; Family with sequence similarity 117 member B | WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape chan [...] | 0.555 |
| KDM5B | FAM117B | ENSP00000356234 | ENSP00000376071 | Lysine-specific demethylase 5B; Histone demethylase that demethylates ’Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’ or H3 ’Lys-27’. Demethylates trimethylated, dimethylated and monomethylated H3 ’Lys-4’. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock [...] | Protein FAM117B; Family with sequence similarity 117 member B | 0.524 |
| MCMBP | DPP3 | ENSP00000353098 | ENSP00000353701 | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion | Dipeptidyl peptidase 3; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro); Belongs to the peptidase M49 family | 0.645 |
| MCMBP | FAM117B | ENSP00000353098 | ENSP00000376071 | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion | Protein FAM117B; Family with sequence similarity 117 member B | 0.622 |
| MCMBP | TSC22D4 | ENSP00000353098 | ENSP00000300181 | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion | TSC22 domain family protein 4; Transcriptional repressor | 0.401 |
| NRBP1 | FAM117B | ENSP00000233557 | ENSP00000376071 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Protein FAM117B; Family with sequence similarity 117 member B | 0.795 |
| NRBP1 | TSC22D2 | ENSP00000233557 | ENSP00000354543 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | TSC22 domain family member 2 | 0.719 |
