• Version:
  • 11.0 [archived version]
STRINGSTRING
COL24A1 COL24A1 PAPSS2 PAPSS2 SUGCT SUGCT NLRP7 NLRP7 DPRX DPRX SP140L SP140L FAM91A1 FAM91A1 SP140 SP140 BLK BLK FAM46C FAM46C NUP210 NUP210
"SP140" - Nuclear body protein SP140 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SP140Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing (867 aa)    
Predicted Functional Partners:
SP140L
SP140 nuclear body protein like; Bromodomain containing (580 aa)
     
 
0.775
DPRX
Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes (191 aa)
       
 
  0.706
BLK
Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] (505 aa)
     
 
  0.673
COL24A1
Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family (1714 aa)
           
  0.658
FAM91A1
Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family (838 aa)
           
  0.652
SUGCT
Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family (445 aa)
           
  0.651
NUP210
Nuclear pore membrane glycoprotein 210; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity; Nucleoporins (1887 aa)
           
  0.593
FAM46C
Putative nucleotidyltransferase FAM46C; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the FAM46 family (391 aa)
     
   
  0.580
PAPSS2
Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have [...] (619 aa)
           
  0.575
NLRP7
NACHT, LRR and PYD domains-containing protein 7; Inhibits CASP1/caspase-1-dependent IL1B secretion; Belongs to the NLRP family (1037 aa)
           
  0.571
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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