node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BLK | SP140 | ENSP00000259089 | ENSP00000375899 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | 0.673 |
BLK | SP140L | ENSP00000259089 | ENSP00000397911 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | SP140 nuclear body protein like; Bromodomain containing | 0.635 |
COL24A1 | DPRX | ENSP00000359603 | ENSP00000365838 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | 0.594 |
COL24A1 | FAM91A1 | ENSP00000359603 | ENSP00000335082 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family | 0.667 |
COL24A1 | NLRP7 | ENSP00000359603 | ENSP00000467123 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | NACHT, LRR and PYD domains-containing protein 7; Inhibits CASP1/caspase-1-dependent IL1B secretion; Belongs to the NLRP family | 0.571 |
COL24A1 | PAPSS2 | ENSP00000359603 | ENSP00000406157 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have [...] | 0.586 |
COL24A1 | SP140 | ENSP00000359603 | ENSP00000375899 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | 0.658 |
COL24A1 | SP140L | ENSP00000359603 | ENSP00000397911 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | SP140 nuclear body protein like; Bromodomain containing | 0.483 |
COL24A1 | SUGCT | ENSP00000359603 | ENSP00000338475 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family | 0.642 |
DPRX | COL24A1 | ENSP00000365838 | ENSP00000359603 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | 0.594 |
DPRX | FAM91A1 | ENSP00000365838 | ENSP00000335082 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family | 0.648 |
DPRX | NLRP7 | ENSP00000365838 | ENSP00000467123 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | NACHT, LRR and PYD domains-containing protein 7; Inhibits CASP1/caspase-1-dependent IL1B secretion; Belongs to the NLRP family | 0.539 |
DPRX | PAPSS2 | ENSP00000365838 | ENSP00000406157 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have [...] | 0.454 |
DPRX | SP140 | ENSP00000365838 | ENSP00000375899 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | 0.706 |
DPRX | SP140L | ENSP00000365838 | ENSP00000397911 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | SP140 nuclear body protein like; Bromodomain containing | 0.514 |
DPRX | SUGCT | ENSP00000365838 | ENSP00000338475 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family | 0.664 |
FAM46C | SP140 | ENSP00000358458 | ENSP00000375899 | Putative nucleotidyltransferase FAM46C; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the FAM46 family | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | 0.580 |
FAM91A1 | COL24A1 | ENSP00000335082 | ENSP00000359603 | Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family | 0.667 |
FAM91A1 | DPRX | ENSP00000335082 | ENSP00000365838 | Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | 0.648 |
FAM91A1 | NLRP7 | ENSP00000335082 | ENSP00000467123 | Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family | NACHT, LRR and PYD domains-containing protein 7; Inhibits CASP1/caspase-1-dependent IL1B secretion; Belongs to the NLRP family | 0.549 |