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  • 11.0 [archived version]
STRINGSTRING
ARF1 ARF1 TRIP11 TRIP11 GCH1 GCH1 ALPP ALPP GGT6 GGT6 PTS PTS ALPI ALPI ALPPL2 ALPPL2 GGT7 GGT7 TPK1 TPK1 NTPCR NTPCR
"ALPP" - Alkaline phosphatase, placental in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ALPPAlkaline phosphatase, placental (535 aa)    
Predicted Functional Partners:
PTS
6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family (145 aa)
          
  0.913
GCH1
GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family (250 aa)
          
  0.910
NTPCR
Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family (190 aa)
          
  0.908
TPK1
Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (243 aa)
      
 
    0.901
ARF1
ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs [...] (181 aa)
          
  0.900
TRIP11
Thyroid receptor-interacting protein 11; Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure (1979 aa)
          
    0.900
ALPPL2
Alkaline phosphatase, placental like 2 (532 aa)
    
 
0.873
ALPI
Alkaline phosphatase, intestinal (528 aa)
    
 
0.855
GGT7
Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases (662 aa)
        
 
  0.713
GGT6
Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases (499 aa)
        
 
  0.697
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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