node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS15 | TEX36 | ENSP00000299164 | ENSP00000357811 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Testis-expressed protein 36; Testis expressed 36 | 0.444 |
ADAMTS15 | ZNF222 | ENSP00000299164 | ENSP00000375822 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | Zinc finger protein 222; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.475 |
CCDC134 | FBXW12 | ENSP00000255784 | ENSP00000296438 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | 0.447 |
CCDC134 | JRKL | ENSP00000255784 | ENSP00000333350 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family | 0.553 |
CCDC134 | USP43 | ENSP00000255784 | ENSP00000285199 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | Ubiquitin carboxyl-terminal hydrolase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity); Belongs to the peptidase C19 family | 0.500 |
CCDC134 | ZNF222 | ENSP00000255784 | ENSP00000375822 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | Zinc finger protein 222; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.541 |
FBXW12 | CCDC134 | ENSP00000296438 | ENSP00000255784 | F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | 0.447 |
FBXW12 | JRKL | ENSP00000296438 | ENSP00000333350 | F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family | 0.429 |
FBXW12 | ZNF222 | ENSP00000296438 | ENSP00000375822 | F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | Zinc finger protein 222; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.475 |
GPR63 | PAFAH2 | ENSP00000229955 | ENSP00000363400 | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans | Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme | 0.420 |
GPR63 | TEX36 | ENSP00000229955 | ENSP00000357811 | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans | Testis-expressed protein 36; Testis expressed 36 | 0.548 |
GPR63 | ZNF222 | ENSP00000229955 | ENSP00000375822 | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans | Zinc finger protein 222; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.563 |
IL11RA | TEX36 | ENSP00000450565 | ENSP00000357811 | Interleukin-11 receptor subunit alpha; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number; Belongs to the type I cytokine receptor family. Type 3 subfamily | Testis-expressed protein 36; Testis expressed 36 | 0.418 |
IL11RA | ZNF222 | ENSP00000450565 | ENSP00000375822 | Interleukin-11 receptor subunit alpha; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number; Belongs to the type I cytokine receptor family. Type 3 subfamily | Zinc finger protein 222; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.447 |
JRKL | CCDC134 | ENSP00000333350 | ENSP00000255784 | Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family | 0.553 |
JRKL | FBXW12 | ENSP00000333350 | ENSP00000296438 | Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family | F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing | 0.429 |
JRKL | USP43 | ENSP00000333350 | ENSP00000285199 | Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family | Ubiquitin carboxyl-terminal hydrolase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity); Belongs to the peptidase C19 family | 0.523 |
JRKL | ZNF222 | ENSP00000333350 | ENSP00000375822 | Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family | Zinc finger protein 222; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.530 |
PAFAH2 | GPR63 | ENSP00000363400 | ENSP00000229955 | Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans | 0.420 |
PAFAH2 | TEX36 | ENSP00000363400 | ENSP00000357811 | Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme | Testis-expressed protein 36; Testis expressed 36 | 0.526 |