MYADM protein (human) - STRING database

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MYADM

Myeloid associated differentiation marker; Belongs to the MAL family (322 aa)

Predicted Functional Partners:

PLLP

0.902

USP49

0.705

ARHGEF40

0.691

TAGAP

0.651

BYSL

0.650

OR5T2

0.612

MKRN1

0.597

RABEPK

0.589

DUS3L

0.585

BTBD19

0.578

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF40	MYADM	ENSP00000298694	ENSP00000375649	Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF)	Myeloid associated differentiation marker; Belongs to the MAL family	0.691
ARHGEF40	TAGAP	ENSP00000298694	ENSP00000356033	Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF)	T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation	0.681
BTBD19	MYADM	ENSP00000395461	ENSP00000375649	BTB/POZ domain-containing protein 19; BTB domain containing 19	Myeloid associated differentiation marker; Belongs to the MAL family	0.578
BYSL	MYADM	ENSP00000230340	ENSP00000375649	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Myeloid associated differentiation marker; Belongs to the MAL family	0.650
BYSL	USP49	ENSP00000230340	ENSP00000377797	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at ’Lys-120’ (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family	0.760
DUS3L	MYADM	ENSP00000311977	ENSP00000375649	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs	Myeloid associated differentiation marker; Belongs to the MAL family	0.585
DUS3L	RABEPK	ENSP00000311977	ENSP00000362639	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs	Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport	0.643
MKRN1	MYADM	ENSP00000255977	ENSP00000375649	E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription; Ring finger proteins	Myeloid associated differentiation marker; Belongs to the MAL family	0.597
MYADM	ARHGEF40	ENSP00000375649	ENSP00000298694	Myeloid associated differentiation marker; Belongs to the MAL family	Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF)	0.691
MYADM	BTBD19	ENSP00000375649	ENSP00000395461	Myeloid associated differentiation marker; Belongs to the MAL family	BTB/POZ domain-containing protein 19; BTB domain containing 19	0.578
MYADM	BYSL	ENSP00000375649	ENSP00000230340	Myeloid associated differentiation marker; Belongs to the MAL family	Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos; Belongs to the bystin family	0.650
MYADM	DUS3L	ENSP00000375649	ENSP00000311977	Myeloid associated differentiation marker; Belongs to the MAL family	tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs	0.585
MYADM	MKRN1	ENSP00000375649	ENSP00000255977	Myeloid associated differentiation marker; Belongs to the MAL family	E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription; Ring finger proteins	0.597
MYADM	OR5T2	ENSP00000375649	ENSP00000323688	Myeloid associated differentiation marker; Belongs to the MAL family	Olfactory receptor 5T2; Odorant receptor; Olfactory receptors, family 5	0.612
MYADM	PLLP	ENSP00000375649	ENSP00000219207	Myeloid associated differentiation marker; Belongs to the MAL family	Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family	0.902
MYADM	RABEPK	ENSP00000375649	ENSP00000362639	Myeloid associated differentiation marker; Belongs to the MAL family	Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport	0.589
MYADM	TAGAP	ENSP00000375649	ENSP00000356033	Myeloid associated differentiation marker; Belongs to the MAL family	T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation	0.651
MYADM	USP49	ENSP00000375649	ENSP00000377797	Myeloid associated differentiation marker; Belongs to the MAL family	Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at ’Lys-120’ (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons; Belongs to the peptidase C19 family	0.705
OR5T2	MYADM	ENSP00000323688	ENSP00000375649	Olfactory receptor 5T2; Odorant receptor; Olfactory receptors, family 5	Myeloid associated differentiation marker; Belongs to the MAL family	0.612
PLLP	MYADM	ENSP00000219207	ENSP00000375649	Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family	Myeloid associated differentiation marker; Belongs to the MAL family	0.902

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