| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CPPED1 | NIF3L1 | ENSP00000371193 | ENSP00000386394 | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.467 |
| CPPED1 | ZNF552 | ENSP00000371193 | ENSP00000375582 | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.484 |
| CREBL2 | DCAF5 | ENSP00000228865 | ENSP00000341351 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.478 |
| CREBL2 | ZCCHC3 | ENSP00000228865 | ENSP00000484056 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | Zinc finger CCHC-type containing 3 | 0.574 |
| CREBL2 | ZNF552 | ENSP00000228865 | ENSP00000375582 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.480 |
| DCAF5 | CREBL2 | ENSP00000341351 | ENSP00000228865 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | 0.478 |
| DCAF5 | SERTAD3 | ENSP00000341351 | ENSP00000325414 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | SERTA domain-containing protein 3; Strong transcriptional coactivator | 0.431 |
| DCAF5 | ZCCHC3 | ENSP00000341351 | ENSP00000484056 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | Zinc finger CCHC-type containing 3 | 0.599 |
| DCAF5 | ZNF552 | ENSP00000341351 | ENSP00000375582 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.514 |
| HIST1H2AD | ZCCHC3 | ENSP00000341094 | ENSP00000484056 | Histone H2A type 1-D; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | Zinc finger CCHC-type containing 3 | 0.489 |
| HIST1H2AD | ZNF552 | ENSP00000341094 | ENSP00000375582 | Histone H2A type 1-D; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.465 |
| LMNTD2 | ZNF552 | ENSP00000331167 | ENSP00000375582 | Lamin tail domain containing 2 | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.407 |
| NIF3L1 | CPPED1 | ENSP00000386394 | ENSP00000371193 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | 0.467 |
| NIF3L1 | ZNF552 | ENSP00000386394 | ENSP00000375582 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.554 |
| SERTAD3 | DCAF5 | ENSP00000325414 | ENSP00000341351 | SERTA domain-containing protein 3; Strong transcriptional coactivator | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.431 |
| SERTAD3 | ZCCHC3 | ENSP00000325414 | ENSP00000484056 | SERTA domain-containing protein 3; Strong transcriptional coactivator | Zinc finger CCHC-type containing 3 | 0.519 |
| SERTAD3 | ZNF552 | ENSP00000325414 | ENSP00000375582 | SERTA domain-containing protein 3; Strong transcriptional coactivator | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.474 |
| TRIM28 | ZNF552 | ENSP00000253024 | ENSP00000375582 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| ZCCHC3 | CREBL2 | ENSP00000484056 | ENSP00000228865 | Zinc finger CCHC-type containing 3 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor; Belongs to the bZIP family. ATF subfamily | 0.574 |
| ZCCHC3 | DCAF5 | ENSP00000484056 | ENSP00000341351 | Zinc finger CCHC-type containing 3 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.599 |
