| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC54 | MRGPRE | ENSP00000261058 | ENSP00000374482 | Coiled-coil domain containing 54 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | 0.469 |
| CCDC54 | RTP3 | ENSP00000261058 | ENSP00000296142 | Coiled-coil domain containing 54 | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family | 0.466 |
| CCDC54 | SULT1C3 | ENSP00000261058 | ENSP00000333310 | Coiled-coil domain containing 54 | Sulfotransferase 1C3; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates; Sulfotransferases, cytosolic | 0.467 |
| GHRH | MRGPRE | ENSP00000362716 | ENSP00000374482 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | 0.517 |
| GHRH | NPS | ENSP00000362716 | ENSP00000381105 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.966 |
| MOB3B | MRGPRE | ENSP00000262244 | ENSP00000374482 | MOB kinase activator 3B; May regulate the activity of kinases; MOB kinase activators | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | 0.522 |
| MORF4L2 | MRGPRE | ENSP00000394417 | ENSP00000374482 | Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | 0.480 |
| MRGPRE | CCDC54 | ENSP00000374482 | ENSP00000261058 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Coiled-coil domain containing 54 | 0.469 |
| MRGPRE | GHRH | ENSP00000374482 | ENSP00000362716 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family | 0.517 |
| MRGPRE | MOB3B | ENSP00000374482 | ENSP00000262244 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | MOB kinase activator 3B; May regulate the activity of kinases; MOB kinase activators | 0.522 |
| MRGPRE | MORF4L2 | ENSP00000374482 | ENSP00000394417 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.480 |
| MRGPRE | NPFF | ENSP00000374482 | ENSP00000267017 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | 0.754 |
| MRGPRE | NPFFR2 | ENSP00000374482 | ENSP00000307822 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Neuropeptide FF receptor 2; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.615 |
| MRGPRE | NPS | ENSP00000374482 | ENSP00000381105 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.540 |
| MRGPRE | OPN1SW | ENSP00000374482 | ENSP00000249389 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Short-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily | 0.682 |
| MRGPRE | RTP3 | ENSP00000374482 | ENSP00000296142 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family | 0.467 |
| MRGPRE | SULT1C3 | ENSP00000374482 | ENSP00000333310 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | Sulfotransferase 1C3; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates; Sulfotransferases, cytosolic | 0.469 |
| NPFF | MRGPRE | ENSP00000267017 | ENSP00000374482 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, Class A orphans | 0.754 |
| NPFF | NPFFR2 | ENSP00000267017 | ENSP00000307822 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | Neuropeptide FF receptor 2; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.994 |
| NPFF | NPS | ENSP00000267017 | ENSP00000381105 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.979 |
