• Version:
  • 11.0 [archived version]
STRINGSTRING
LRRC3 LRRC3 MEPE MEPE CDC14B CDC14B ZXDA ZXDA CIITA CIITA ZXDC ZXDC PPP2R2C PPP2R2C CBR4 CBR4 CCL2 CCL2 MRPS23 MRPS23 ARMC10 ARMC10
"ZXDC" - Zinc finger protein ZXDC in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ZXDCZinc finger protein ZXDC; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Zinc fingers C2H2-type (858 aa)    
Predicted Functional Partners:
CIITA
MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirem [...] (1131 aa)
       
 
  0.788
CBR4
Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10- phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro); Short chain dehydrogenase/reductase superfamily (237 aa)
       
      0.553
MEPE
Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family (525 aa)
       
      0.548
MRPS23
Mitochondrial ribosomal protein S23; Belongs to the mitochondrion-specific ribosomal protein mS23 family (190 aa)
           
  0.514
CCL2
C-C motif chemokine 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis; Belongs to the intercrine beta (chemokine CC) family (99 aa)
           
  0.475
ARMC10
Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53; Armadillo repeat containing (343 aa)
           
  0.463
CDC14B
Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases; Belongs to the protein-tyrosine ph [...] (498 aa)
       
 
  0.438
LRRC3
Leucine-rich repeat-containing protein 3; Leucine rich repeat containing 3 (257 aa)
       
 
  0.435
ZXDA
Zinc finger X-linked protein ZXDA; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Zinc fingers C2H2-type (799 aa)
     
 
0.424
PPP2R2C
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment (447 aa)
       
 
  0.419
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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