HAGHL protein (human) - STRING database

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HAGHL

Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds (282 aa)

Predicted Functional Partners:

PRR29

0.671

MBLAC1

0.653

MBLAC2

0.650

CSRNP2

0.596

C1orf174

0.587

NMRAL1

0.572

DHX32

0.556

KIAA2026

0.526

EPN3

0.511

OSER1

0.480

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf174	CSRNP2	ENSP00000355306	ENSP00000228515	UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family	Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits	0.556
C1orf174	HAGHL	ENSP00000355306	ENSP00000374353	UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	0.587
C1orf174	KIAA2026	ENSP00000355306	ENSP00000382815	UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family	Uncharacterized protein KIAA2026; KIAA2026	0.571
C1orf174	NMRAL1	ENSP00000355306	ENSP00000458762	UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family	NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer b [...]	0.496
C1orf174	OSER1	ENSP00000355306	ENSP00000362061	UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family	Oxidative stress-responsive serine-rich protein 1; Oxidative stress responsive serine rich 1	0.530
CSRNP2	C1orf174	ENSP00000228515	ENSP00000355306	Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits	UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family	0.556
CSRNP2	HAGHL	ENSP00000228515	ENSP00000374353	Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	0.596
CSRNP2	KIAA2026	ENSP00000228515	ENSP00000382815	Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits	Uncharacterized protein KIAA2026; KIAA2026	0.473
CSRNP2	NMRAL1	ENSP00000228515	ENSP00000458762	Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits	NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer b [...]	0.573
CSRNP2	OSER1	ENSP00000228515	ENSP00000362061	Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits	Oxidative stress-responsive serine-rich protein 1; Oxidative stress responsive serine rich 1	0.442
DHX32	HAGHL	ENSP00000284690	ENSP00000374353	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DEAH-box helicase 32; Belongs to the DEAD box helicase family. DEAH subfamily	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	0.556
EPN3	HAGHL	ENSP00000268933	ENSP00000374353	Epsin-3; Epsin 3; Belongs to the epsin family	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	0.511
EPN3	PRR29	ENSP00000268933	ENSP00000396936	Epsin-3; Epsin 3; Belongs to the epsin family	Proline-rich protein 29; Proline rich 29	0.557
HAGHL	C1orf174	ENSP00000374353	ENSP00000355306	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family	0.587
HAGHL	CSRNP2	ENSP00000374353	ENSP00000228515	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits	0.596
HAGHL	DHX32	ENSP00000374353	ENSP00000284690	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DEAH-box helicase 32; Belongs to the DEAD box helicase family. DEAH subfamily	0.556
HAGHL	EPN3	ENSP00000374353	ENSP00000268933	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	Epsin-3; Epsin 3; Belongs to the epsin family	0.511
HAGHL	KIAA2026	ENSP00000374353	ENSP00000382815	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	Uncharacterized protein KIAA2026; KIAA2026	0.526
HAGHL	MBLAC1	ENSP00000374353	ENSP00000381150	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	Metallo-beta-lactamase domain containing 1	0.653
HAGHL	MBLAC2	ENSP00000374353	ENSP00000314776	Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds	Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family	0.650

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