| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APP | LRP1B | ENSP00000284981 | ENSP00000374135 | Amyloid-beta A4 protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.620 |
| CADM2 | CSMD3 | ENSP00000384193 | ENSP00000297405 | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.458 |
| CADM2 | FAIM2 | ENSP00000384193 | ENSP00000321951 | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | 0.690 |
| CADM2 | LRP1B | ENSP00000384193 | ENSP00000374135 | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.575 |
| CADM2 | QPCTL | ENSP00000384193 | ENSP00000012049 | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides | 0.630 |
| CADM2 | TMEM160 | ENSP00000384193 | ENSP00000253047 | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | Transmembrane protein 160 | 0.585 |
| CSMD3 | CADM2 | ENSP00000297405 | ENSP00000384193 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | 0.458 |
| CSMD3 | LRP1B | ENSP00000297405 | ENSP00000374135 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.552 |
| CSMD3 | PTPRD | ENSP00000297405 | ENSP00000370593 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2; Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily | 0.452 |
| DVL2 | LRP1B | ENSP00000005340 | ENSP00000374135 | Segment polarity protein dishevelled homolog DVL-2; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C- terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling; Belongs to the DSH family | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.538 |
| FAIM2 | CADM2 | ENSP00000321951 | ENSP00000384193 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | 0.690 |
| FAIM2 | LRP1B | ENSP00000321951 | ENSP00000374135 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.537 |
| FAIM2 | QPCTL | ENSP00000321951 | ENSP00000012049 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides | 0.568 |
| FAIM2 | TMEM160 | ENSP00000321951 | ENSP00000253047 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | Transmembrane protein 160 | 0.587 |
| FHIT | LRP1B | ENSP00000417480 | ENSP00000374135 | Bis(5’-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5’-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5’- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptos [...] | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.538 |
| FHIT | PTPRD | ENSP00000417480 | ENSP00000370593 | Bis(5’-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5’-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5’- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptos [...] | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2; Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily | 0.491 |
| LRP11 | LRP1B | ENSP00000239367 | ENSP00000374135 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | 0.574 |
| LRP1B | APP | ENSP00000374135 | ENSP00000284981 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | Amyloid-beta A4 protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands | 0.620 |
| LRP1B | CADM2 | ENSP00000374135 | ENSP00000384193 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes; C2-set domain containing | 0.575 |
| LRP1B | CSMD3 | ENSP00000374135 | ENSP00000297405 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein receptors | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing | 0.552 |
