node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGAP2 | C2orf81 | ENSP00000449241 | ENSP00000290390 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also r [...] | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | 0.477 |
AGAP2 | CCDC154 | ENSP00000449241 | ENSP00000373828 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also r [...] | Coiled-coil domain containing 154 | 0.492 |
C2orf81 | AGAP2 | ENSP00000290390 | ENSP00000449241 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also r [...] | 0.477 |
C2orf81 | C7orf73 | ENSP00000290390 | ENSP00000425996 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | 0.709 |
C2orf81 | CCDC154 | ENSP00000290390 | ENSP00000373828 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Coiled-coil domain containing 154 | 0.789 |
C2orf81 | JAKMIP3 | ENSP00000290390 | ENSP00000298622 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Janus kinase and microtubule interacting protein 3 | 0.641 |
C2orf81 | KIAA1683 | ENSP00000290390 | ENSP00000376213 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | IQ domain-containing protein N; KIAA1683 | 0.670 |
C2orf81 | MYO3B | ENSP00000290390 | ENSP00000386213 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...] | 0.561 |
C2orf81 | PPAP2C | ENSP00000290390 | ENSP00000329697 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Phospholipid phosphatase 2; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P; Belongs to the PA-phosphatase related phosphoesterase family | 0.533 |
C2orf81 | RHBDF1 | ENSP00000290390 | ENSP00000262316 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration | 0.528 |
C2orf81 | TCEB3B | ENSP00000290390 | ENSP00000331302 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | Elongin-A2; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.708 |
C7orf73 | C2orf81 | ENSP00000425996 | ENSP00000290390 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 | 0.709 |
C7orf73 | CCDC154 | ENSP00000425996 | ENSP00000373828 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | Coiled-coil domain containing 154 | 0.709 |
C7orf73 | JAKMIP3 | ENSP00000425996 | ENSP00000298622 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | Janus kinase and microtubule interacting protein 3 | 0.550 |
C7orf73 | KIAA1683 | ENSP00000425996 | ENSP00000376213 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | IQ domain-containing protein N; KIAA1683 | 0.590 |
C7orf73 | MYO3B | ENSP00000425996 | ENSP00000386213 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...] | 0.471 |
C7orf73 | PPAP2C | ENSP00000425996 | ENSP00000329697 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | Phospholipid phosphatase 2; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P; Belongs to the PA-phosphatase related phosphoesterase family | 0.440 |
C7orf73 | RHBDF1 | ENSP00000425996 | ENSP00000262316 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration | 0.429 |
C7orf73 | TCEB3B | ENSP00000425996 | ENSP00000331302 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 | Elongin-A2; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) | 0.669 |
CCDC154 | AGAP2 | ENSP00000373828 | ENSP00000449241 | Coiled-coil domain containing 154 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also r [...] | 0.492 |