node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMPR1A | FAM83G | ENSP00000361107 | ENSP00000373647 | Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.570 |
CD2AP | FAM83G | ENSP00000352264 | ENSP00000373647 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.480 |
CHD6 | FAM83G | ENSP00000362330 | ENSP00000373647 | Chromodomain-helicase-DNA-binding protein 6; DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2; Myb/SANT domain containing | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.434 |
CSNK1A1 | CSNK1A1L | ENSP00000421689 | ENSP00000369126 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | Casein kinase I isoform alpha-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity) | 0.801 |
CSNK1A1 | FAM83G | ENSP00000421689 | ENSP00000373647 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.483 |
CSNK1A1L | CSNK1A1 | ENSP00000369126 | ENSP00000421689 | Casein kinase I isoform alpha-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity) | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | 0.801 |
CSNK1A1L | FAM83G | ENSP00000369126 | ENSP00000373647 | Casein kinase I isoform alpha-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity) | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.449 |
ECHDC2 | FAM83G | ENSP00000360577 | ENSP00000373647 | Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.488 |
FAM83G | BMPR1A | ENSP00000373647 | ENSP00000361107 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.570 |
FAM83G | CD2AP | ENSP00000373647 | ENSP00000352264 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glom [...] | 0.480 |
FAM83G | CHD6 | ENSP00000373647 | ENSP00000362330 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Chromodomain-helicase-DNA-binding protein 6; DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2; Myb/SANT domain containing | 0.434 |
FAM83G | CSNK1A1 | ENSP00000373647 | ENSP00000421689 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at ’Ser-45’. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration | 0.483 |
FAM83G | CSNK1A1L | ENSP00000373647 | ENSP00000369126 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Casein kinase I isoform alpha-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity) | 0.449 |
FAM83G | ECHDC2 | ENSP00000373647 | ENSP00000360577 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family | 0.488 |
FAM83G | MC1R | ENSP00000373647 | ENSP00000451605 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family | 0.471 |
FAM83G | PYROXD1 | ENSP00000373647 | ENSP00000240651 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Involved in cellular response to oxidative stress; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily | 0.723 |
FAM83G | SLC5A10 | ENSP00000373647 | ENSP00000379008 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.770 |
FAM83G | TPRKB | ENSP00000373647 | ENSP00000272424 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | EKC/KEOPS complex subunit TPRKB; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity); Belongs to the CGI121/TPRKB family | 0.440 |
MC1R | FAM83G | ENSP00000451605 | ENSP00000373647 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.471 |
PYROXD1 | FAM83G | ENSP00000240651 | ENSP00000373647 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Involved in cellular response to oxidative stress; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.723 |