C15orf27 protein (human) - STRING database

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C15orf27

Transmembrane protein 266; Chromosome 15 open reading frame 27 (531 aa)

Predicted Functional Partners:

TGFBRAP1

0.802

VPS11

0.795

TPTE

0.786

TPTE2

0.741

PPP1R8

0.518

SCAPER

0.474

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf27	PPP1R8	ENSP00000373594	ENSP00000311677	Transmembrane protein 266; Chromosome 15 open reading frame 27	Nuclear inhibitor of protein phosphatase 1; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation	0.518
C15orf27	SCAPER	ENSP00000373594	ENSP00000454973	Transmembrane protein 266; Chromosome 15 open reading frame 27	S phase cyclin A-associated protein in the endoplasmic reticulum; CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm; Zinc fingers C2H2-type	0.474
C15orf27	TGFBRAP1	ENSP00000373594	ENSP00000377027	Transmembrane protein 266; Chromosome 15 open reading frame 27	Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2	0.802
C15orf27	TPTE	ENSP00000373594	ENSP00000484403	Transmembrane protein 266; Chromosome 15 open reading frame 27	Putative tyrosine-protein phosphatase TPTE; Could be involved in signal transduction; C2 tensin-type domain containing	0.786
C15orf27	TPTE2	ENSP00000373594	ENSP00000383089	Transmembrane protein 266; Chromosome 15 open reading frame 27	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; C2 tensin-type domain containing	0.741
C15orf27	VPS11	ENSP00000373594	ENSP00000481126	Transmembrane protein 266; Chromosome 15 open reading frame 27	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...]	0.795
PPP1R8	C15orf27	ENSP00000311677	ENSP00000373594	Nuclear inhibitor of protein phosphatase 1; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation	Transmembrane protein 266; Chromosome 15 open reading frame 27	0.518
SCAPER	C15orf27	ENSP00000454973	ENSP00000373594	S phase cyclin A-associated protein in the endoplasmic reticulum; CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm; Zinc fingers C2H2-type	Transmembrane protein 266; Chromosome 15 open reading frame 27	0.474
TGFBRAP1	C15orf27	ENSP00000377027	ENSP00000373594	Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2	Transmembrane protein 266; Chromosome 15 open reading frame 27	0.802
TGFBRAP1	VPS11	ENSP00000377027	ENSP00000481126	Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...]	0.996
TPTE	C15orf27	ENSP00000484403	ENSP00000373594	Putative tyrosine-protein phosphatase TPTE; Could be involved in signal transduction; C2 tensin-type domain containing	Transmembrane protein 266; Chromosome 15 open reading frame 27	0.786
TPTE2	C15orf27	ENSP00000383089	ENSP00000373594	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; C2 tensin-type domain containing	Transmembrane protein 266; Chromosome 15 open reading frame 27	0.741
VPS11	C15orf27	ENSP00000481126	ENSP00000373594	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...]	Transmembrane protein 266; Chromosome 15 open reading frame 27	0.795
VPS11	TGFBRAP1	ENSP00000481126	ENSP00000377027	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...]	Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2	0.996

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