• Version:
  • 11.0 [archived version]
STRINGSTRING
MYCBP2 MYCBP2 FAM171B FAM171B C2orf54 C2orf54 SEPT2 SEPT2 ANO7 ANO7 THAP4 THAP4 DTYMK DTYMK FARP2 FARP2 SNED1 SNED1 ANKMY1 ANKMY1 STK25 STK25
"C2orf54" - Uncharacterized protein C2orf54 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C2orf54Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54 (447 aa)    
Predicted Functional Partners:
THAP4
THAP domain containing 4 (577 aa)
           
  0.707
ANKMY1
Ankyrin repeat and MYND domain containing 1 (1030 aa)
           
  0.697
DTYMK
Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family (212 aa)
           
  0.648
ANO7
Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions; Anoctamins (933 aa)
           
  0.631
MYCBP2
E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family (4640 aa)
           
  0.629
SNED1
Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing (1413 aa)
           
  0.625
SEPT2
Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the [...] (396 aa)
           
  0.616
FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity); FERM domain containing (1054 aa)
           
  0.611
STK25
Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (426 aa)
           
  0.600
FAM171B
Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family (826 aa)
           
  0.594
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]