FOXI2 protein (human) - STRING database

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FOXI2

Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes (318 aa)

Predicted Functional Partners:

PAX8

0.758

DLX3

0.658

SOX5

0.655

ZDHHC14

0.599

SOX11

0.568

FGF3

0.566

ZSCAN18

0.561

ZNF471

0.560

CLVS1

0.549

CCDC88C

0.536

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC88C	CLVS1	ENSP00000374507	ENSP00000428402	Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family	Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)	0.659
CCDC88C	FOXI2	ENSP00000374507	ENSP00000373572	Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	0.536
CCDC88C	ZDHHC14	ENSP00000374507	ENSP00000352821	Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family	Probable palmitoyltransferase ZDHHC14; Zinc finger DHHC-type containing 14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily	0.561
CLVS1	CCDC88C	ENSP00000428402	ENSP00000374507	Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)	Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family	0.659
CLVS1	FOXI2	ENSP00000428402	ENSP00000373572	Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	0.549
CLVS1	ZDHHC14	ENSP00000428402	ENSP00000352821	Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)	Probable palmitoyltransferase ZDHHC14; Zinc finger DHHC-type containing 14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily	0.611
DLX3	FGF3	ENSP00000389870	ENSP00000334122	Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the heparin-binding growth factors family	0.510
DLX3	FOXI2	ENSP00000389870	ENSP00000373572	Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	0.658
DLX3	PAX8	ENSP00000389870	ENSP00000263334	Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family	Paired box protein Pax-8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells; PRD class homeoboxes and pseudogenes	0.555
FGF3	DLX3	ENSP00000334122	ENSP00000389870	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the heparin-binding growth factors family	Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family	0.510
FGF3	FOXI2	ENSP00000334122	ENSP00000373572	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the heparin-binding growth factors family	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	0.566
FGF3	PAX8	ENSP00000334122	ENSP00000263334	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the heparin-binding growth factors family	Paired box protein Pax-8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells; PRD class homeoboxes and pseudogenes	0.596
FOXI2	CCDC88C	ENSP00000373572	ENSP00000374507	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family	0.536
FOXI2	CLVS1	ENSP00000373572	ENSP00000428402	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)	0.549
FOXI2	DLX3	ENSP00000373572	ENSP00000389870	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family	0.658
FOXI2	FGF3	ENSP00000373572	ENSP00000334122	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the heparin-binding growth factors family	0.566
FOXI2	PAX8	ENSP00000373572	ENSP00000263334	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Paired box protein Pax-8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells; PRD class homeoboxes and pseudogenes	0.758
FOXI2	SOX11	ENSP00000373572	ENSP00000322568	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Transcription factor SOX-11; Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development; SRY-boxes	0.568
FOXI2	SOX5	ENSP00000373572	ENSP00000398273	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes	0.655
FOXI2	ZDHHC14	ENSP00000373572	ENSP00000352821	Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes	Probable palmitoyltransferase ZDHHC14; Zinc finger DHHC-type containing 14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily	0.599

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