| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EPHA3 | RUFY1 | ENSP00000337451 | ENSP00000325594 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in car [...] | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | 0.956 |
| EPHA3 | RUFY2 | ENSP00000337451 | ENSP00000373420 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in car [...] | RUN and FYVE domain containing 2; Zinc fingers FYVE-type | 0.819 |
| MYPN | PBLD | ENSP00000351790 | ENSP00000351619 | Myopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines; Belongs to the myotilin/palladin family | Phenazine biosynthesis like protein domain containing | 0.724 |
| MYPN | RUFY2 | ENSP00000351790 | ENSP00000373420 | Myopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines; Belongs to the myotilin/palladin family | RUN and FYVE domain containing 2; Zinc fingers FYVE-type | 0.526 |
| MYPN | SLC25A16 | ENSP00000351790 | ENSP00000476815 | Myopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines; Belongs to the myotilin/palladin family | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Solute carriers | 0.406 |
| PBLD | MYPN | ENSP00000351619 | ENSP00000351790 | Phenazine biosynthesis like protein domain containing | Myopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines; Belongs to the myotilin/palladin family | 0.724 |
| PBLD | RUFY1 | ENSP00000351619 | ENSP00000325594 | Phenazine biosynthesis like protein domain containing | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | 0.405 |
| PBLD | RUFY2 | ENSP00000351619 | ENSP00000373420 | Phenazine biosynthesis like protein domain containing | RUN and FYVE domain containing 2; Zinc fingers FYVE-type | 0.709 |
| PBLD | SLC25A16 | ENSP00000351619 | ENSP00000476815 | Phenazine biosynthesis like protein domain containing | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Solute carriers | 0.629 |
| RAB33A | RAB33B | ENSP00000257017 | ENSP00000306496 | Ras-related protein Rab-33A; RAB33A, member RAS oncogene family | Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation; RAB, member RAS oncogene GTPases | 0.905 |
| RAB33A | RUFY2 | ENSP00000257017 | ENSP00000373420 | Ras-related protein Rab-33A; RAB33A, member RAS oncogene family | RUN and FYVE domain containing 2; Zinc fingers FYVE-type | 0.574 |
| RAB33A | RUFY3 | ENSP00000257017 | ENSP00000370394 | Ras-related protein Rab-33A; RAB33A, member RAS oncogene family | Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and inva [...] | 0.525 |
| RAB33A | RUFY4 | ENSP00000257017 | ENSP00000363270 | Ras-related protein Rab-33A; RAB33A, member RAS oncogene family | RUN and FYVE domain containing 4; Zinc fingers FYVE-type | 0.539 |
| RAB33B | RAB33A | ENSP00000306496 | ENSP00000257017 | Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation; RAB, member RAS oncogene GTPases | Ras-related protein Rab-33A; RAB33A, member RAS oncogene family | 0.905 |
| RAB33B | RUFY2 | ENSP00000306496 | ENSP00000373420 | Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation; RAB, member RAS oncogene GTPases | RUN and FYVE domain containing 2; Zinc fingers FYVE-type | 0.571 |
| RUFY1 | EPHA3 | ENSP00000325594 | ENSP00000337451 | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in car [...] | 0.956 |
| RUFY1 | PBLD | ENSP00000325594 | ENSP00000351619 | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | Phenazine biosynthesis like protein domain containing | 0.405 |
| RUFY1 | RUFY2 | ENSP00000325594 | ENSP00000373420 | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | RUN and FYVE domain containing 2; Zinc fingers FYVE-type | 0.815 |
| RUFY1 | RUFY3 | ENSP00000325594 | ENSP00000370394 | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and inva [...] | 0.522 |
| RUFY1 | RUSC2 | ENSP00000325594 | ENSP00000393922 | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type | Iporin; RUN and SH3 domain containing 2 | 0.431 |
