node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACMSD | DNAJC27 | ENSP00000348459 | ENSP00000264711 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway; Belongs to the metallo-dependent [...] | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; DNAJ heat shock proteins | 0.679 |
ACMSD | UROC1 | ENSP00000348459 | ENSP00000373073 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway; Belongs to the metallo-dependent [...] | Urocanate hydratase 1 | 0.568 |
AMDHD1 | FTCD | ENSP00000266736 | ENSP00000291670 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | 0.971 |
AMDHD1 | HAL | ENSP00000266736 | ENSP00000261208 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Histidine ammonia-lyase | 0.911 |
AMDHD1 | UROC1 | ENSP00000266736 | ENSP00000373073 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | Urocanate hydratase 1 | 0.987 |
CHN1 | UROC1 | ENSP00000386741 | ENSP00000373073 | N-chimaerin; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance | Urocanate hydratase 1 | 0.496 |
CPB2 | FTCD | ENSP00000181383 | ENSP00000291670 | Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | 0.677 |
CPB2 | HAL | ENSP00000181383 | ENSP00000261208 | Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family | Histidine ammonia-lyase | 0.549 |
CPB2 | UROC1 | ENSP00000181383 | ENSP00000373073 | Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family | Urocanate hydratase 1 | 0.566 |
DNAJC27 | ACMSD | ENSP00000264711 | ENSP00000348459 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; DNAJ heat shock proteins | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway; Belongs to the metallo-dependent [...] | 0.679 |
DNAJC27 | UROC1 | ENSP00000264711 | ENSP00000373073 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; DNAJ heat shock proteins | Urocanate hydratase 1 | 0.649 |
ECD | UROC1 | ENSP00000401566 | ENSP00000373073 | Protein ecdysoneless homolog; Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the [...] | Urocanate hydratase 1 | 0.506 |
FTCD | AMDHD1 | ENSP00000291670 | ENSP00000266736 | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | 0.971 |
FTCD | CPB2 | ENSP00000291670 | ENSP00000181383 | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family | 0.677 |
FTCD | HAL | ENSP00000291670 | ENSP00000261208 | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | Histidine ammonia-lyase | 0.612 |
FTCD | UROC1 | ENSP00000291670 | ENSP00000373073 | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family | Urocanate hydratase 1 | 0.805 |
GFOD2 | UROC1 | ENSP00000268797 | ENSP00000373073 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly | Urocanate hydratase 1 | 0.738 |
HACL1 | UROC1 | ENSP00000323811 | ENSP00000373073 | 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde; Belongs to the TPP enzyme family | Urocanate hydratase 1 | 0.650 |
HAL | AMDHD1 | ENSP00000261208 | ENSP00000266736 | Histidine ammonia-lyase | Probable imidazolonepropionase; Amidohydrolase domain containing 1 | 0.911 |
HAL | CPB2 | ENSP00000261208 | ENSP00000181383 | Histidine ammonia-lyase | Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family | 0.549 |