node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD12 | LRRC30 | ENSP00000262126 | ENSP00000372959 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.781 |
ANKRD12 | PPP4R1 | ENSP00000262126 | ENSP00000383402 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | Serine/threonine-protein phosphatase 4 regulatory subunit 1; Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3; Armadillo-like helical domain containing | 0.407 |
ANKRD12 | ZBTB14 | ENSP00000262126 | ENSP00000349503 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | Zinc finger and BTB domain-containing protein 14; Transcriptional activator of the dopamine transporter (DAT), binding it’s promoter at the consensus sequence 5’- CCTGCACAGTTCACGGA-3’. Binds to 5’-d(GCC)(n)-3’ trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters; BTB domain containing | 0.684 |
ATP1B4 | CDNF | ENSP00000218008 | ENSP00000419395 | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the X(+)/potassium ATPases subunit beta family | Cerebral dopamine neurotrophic factor; Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity) | 0.511 |
ATP1B4 | CHRNA1 | ENSP00000218008 | ENSP00000261007 | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the X(+)/potassium ATPases subunit beta family | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | 0.701 |
ATP1B4 | LRRC30 | ENSP00000218008 | ENSP00000372959 | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the X(+)/potassium ATPases subunit beta family | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.841 |
C1QL1 | LRRC30 | ENSP00000253407 | ENSP00000372959 | C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.693 |
CDNF | ATP1B4 | ENSP00000419395 | ENSP00000218008 | Cerebral dopamine neurotrophic factor; Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity) | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the X(+)/potassium ATPases subunit beta family | 0.511 |
CDNF | LRRC30 | ENSP00000419395 | ENSP00000372959 | Cerebral dopamine neurotrophic factor; Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity) | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.759 |
CHRNA1 | ATP1B4 | ENSP00000261007 | ENSP00000218008 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the X(+)/potassium ATPases subunit beta family | 0.701 |
CHRNA1 | LRRC30 | ENSP00000261007 | ENSP00000372959 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.654 |
LPHN1 | LRRC30 | ENSP00000340688 | ENSP00000372959 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.685 |
LPHN2 | LRRC30 | ENSP00000322270 | ENSP00000372959 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.685 |
LPHN3 | LRRC30 | ENSP00000422533 | ENSP00000372959 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | 0.685 |
LRRC30 | ANKRD12 | ENSP00000372959 | ENSP00000262126 | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | 0.781 |
LRRC30 | ATP1B4 | ENSP00000372959 | ENSP00000218008 | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the X(+)/potassium ATPases subunit beta family | 0.841 |
LRRC30 | C1QL1 | ENSP00000372959 | ENSP00000253407 | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related | 0.693 |
LRRC30 | CDNF | ENSP00000372959 | ENSP00000419395 | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | Cerebral dopamine neurotrophic factor; Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity) | 0.759 |
LRRC30 | CHRNA1 | ENSP00000372959 | ENSP00000261007 | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Cholinergic receptors nicotinic subunits | 0.654 |
LRRC30 | LPHN1 | ENSP00000372959 | ENSP00000340688 | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.685 |