GJB2 protein (human) - STRING database

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GJB2

Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes (226 aa)

Predicted Functional Partners:

GJB1

0.938

SLC26A4

0.899

PANX1

0.780

PANX2

0.774

PANX3

0.753

TMIE

0.747

CNST

0.741

TMC1

0.741

GJA8

0.740

OTOF

0.739

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNST	GJB1	ENSP00000355470	ENSP00000363134	Consortin; Required for targeting of connexins to the plasma membrane; Protein phosphatase 1 regulatory subunits	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.771
CNST	GJB2	ENSP00000355470	ENSP00000372295	Consortin; Required for targeting of connexins to the plasma membrane; Protein phosphatase 1 regulatory subunits	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	0.741
GJA8	GJB1	ENSP00000358238	ENSP00000363134	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.740
GJA8	GJB2	ENSP00000358238	ENSP00000372295	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	0.740
GJA8	PANX1	ENSP00000358238	ENSP00000227638	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Pannexins	0.670
GJA8	PANX2	ENSP00000358238	ENSP00000379183	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Pannexin-2; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family	0.670
GJA8	PANX3	ENSP00000358238	ENSP00000284288	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Pannexin-3; Structural component of the gap junctions and the hemichannels; Pannexins	0.677
GJB1	CNST	ENSP00000363134	ENSP00000355470	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Consortin; Required for targeting of connexins to the plasma membrane; Protein phosphatase 1 regulatory subunits	0.771
GJB1	GJA8	ENSP00000363134	ENSP00000358238	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.740
GJB1	GJB2	ENSP00000363134	ENSP00000372295	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	0.938
GJB1	PANX1	ENSP00000363134	ENSP00000227638	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Pannexins	0.785
GJB1	PANX2	ENSP00000363134	ENSP00000379183	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Pannexin-2; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family	0.785
GJB1	PANX3	ENSP00000363134	ENSP00000284288	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	Pannexin-3; Structural component of the gap junctions and the hemichannels; Pannexins	0.795
GJB2	CNST	ENSP00000372295	ENSP00000355470	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	Consortin; Required for targeting of connexins to the plasma membrane; Protein phosphatase 1 regulatory subunits	0.741
GJB2	GJA8	ENSP00000372295	ENSP00000358238	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.740
GJB2	GJB1	ENSP00000372295	ENSP00000363134	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.938
GJB2	OTOF	ENSP00000372295	ENSP00000272371	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity); Deafness associated genes	0.739
GJB2	PANX1	ENSP00000372295	ENSP00000227638	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Pannexins	0.780
GJB2	PANX2	ENSP00000372295	ENSP00000379183	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	Pannexin-2; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family	0.774
GJB2	PANX3	ENSP00000372295	ENSP00000284288	Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes	Pannexin-3; Structural component of the gap junctions and the hemichannels; Pannexins	0.753

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