• Version:
  • 11.0 [archived version]
STRINGSTRING
STX1A STX1A VAPA VAPA TRAK1 TRAK1 SNPH SNPH KCNAB3 KCNAB3 RHOT1 RHOT1 KCNH3 KCNH3 KCNF1 KCNF1 TRAK2 TRAK2 GABRA5 GABRA5 OPCML OPCML
"SNPH" - Syntaphilin in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SNPHSyntaphilin; Inhibits SNARE complex formation by absorbing free syntaxin-1 (494 aa)    
Predicted Functional Partners:
STX1A
Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins (288 aa)
     
 
  0.854
RHOT1
Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution; EF-hand domain containing (691 aa)
           
  0.776
KCNH3
Potassium voltage-gated channel subfamily H member 3; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily (1083 aa)
     
   
  0.742
OPCML
Opioid-binding protein/cell adhesion molecule; Binds opioids in the presence of acidic lipids; probably involved in cell contact; Belongs to the immunoglobulin superfamily. IgLON family (345 aa)
     
   
  0.716
VAPA
Vesicle-associated membrane protein-associated protein A; VAMP associated protein A (294 aa)
           
  0.710
KCNF1
Potassium voltage-gated channel subfamily F member 1; Putative voltage-gated potassium channel; Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily (494 aa)
     
   
  0.704
KCNAB3
Voltage-gated potassium channel subunit beta-3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5; Aldo-keto reductases (404 aa)
           
  0.687
TRAK2
Trafficking kinesin-binding protein 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR (914 aa)
     
   
  0.684
TRAK1
Trafficking kinesin-binding protein 1; Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (953 aa)
     
   
  0.679
GABRA5
Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits (462 aa)
     
   
  0.661
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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