| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOBEC1 | RBM47 | ENSP00000229304 | ENSP00000371212 | C->U-editing enzyme APOBEC-1; Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation; Belongs to the cytidine and deoxycytidylate deaminase family | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.480 |
| C2CD2 | RBM47 | ENSP00000369853 | ENSP00000371212 | C2 calcium dependent domain containing 2 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.515 |
| C2CD2 | TRAPPC1 | ENSP00000369853 | ENSP00000302783 | C2 calcium dependent domain containing 2 | Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily | 0.679 |
| C2CD2 | ZNF805 | ENSP00000369853 | ENSP00000412999 | C2 calcium dependent domain containing 2 | Zinc finger protein 805; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.702 |
| ERLIN2 | RBM47 | ENSP00000276461 | ENSP00000371212 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.495 |
| ESRP1 | ESRP2 | ENSP00000405738 | ENSP00000418748 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2; Belongs to the ESRP family | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 | 0.928 |
| ESRP1 | RBM47 | ENSP00000405738 | ENSP00000371212 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2; Belongs to the ESRP family | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.588 |
| ESRP1 | RBPMS2 | ENSP00000405738 | ENSP00000300069 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2; Belongs to the ESRP family | RNA-binding protein with multiple splicing 2; Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation; RNA binding motif containing | 0.909 |
| ESRP2 | ESRP1 | ENSP00000418748 | ENSP00000405738 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2; Belongs to the ESRP family | 0.928 |
| ESRP2 | RBM47 | ENSP00000418748 | ENSP00000371212 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.604 |
| ESRP2 | RBPMS2 | ENSP00000418748 | ENSP00000300069 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 | RNA-binding protein with multiple splicing 2; Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation; RNA binding motif containing | 0.403 |
| KIAA0895 | RBM47 | ENSP00000297063 | ENSP00000371212 | Uncharacterized protein KIAA0895; KIAA0895 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | 0.548 |
| RBM47 | APOBEC1 | ENSP00000371212 | ENSP00000229304 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | C->U-editing enzyme APOBEC-1; Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation; Belongs to the cytidine and deoxycytidylate deaminase family | 0.480 |
| RBM47 | C2CD2 | ENSP00000371212 | ENSP00000369853 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | C2 calcium dependent domain containing 2 | 0.515 |
| RBM47 | ERLIN2 | ENSP00000371212 | ENSP00000276461 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | 0.495 |
| RBM47 | ESRP1 | ENSP00000371212 | ENSP00000405738 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2; Belongs to the ESRP family | 0.588 |
| RBM47 | ESRP2 | ENSP00000371212 | ENSP00000418748 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 | 0.604 |
| RBM47 | KIAA0895 | ENSP00000371212 | ENSP00000297063 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | Uncharacterized protein KIAA0895; KIAA0895 | 0.548 |
| RBM47 | RBPMS2 | ENSP00000371212 | ENSP00000300069 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | RNA-binding protein with multiple splicing 2; Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation; RNA binding motif containing | 0.558 |
| RBM47 | TRAPPC1 | ENSP00000371212 | ENSP00000302783 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family | Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily | 0.495 |
