| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARRDC5 | C4orf17 | ENSP00000371200 | ENSP00000322582 | Arrestin domain containing 5; Belongs to the arrestin family | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17 | 0.796 |
| ARRDC5 | DSCR3 | ENSP00000371200 | ENSP00000311399 | Arrestin domain containing 5; Belongs to the arrestin family | Down syndrome critical region gene 3; Belongs to the VPS26 family | 0.578 |
| ARRDC5 | LKAAEAR1 | ENSP00000371200 | ENSP00000310801 | Arrestin domain containing 5; Belongs to the arrestin family | Protein LKAAEAR1; LKAAEAR motif containing 1 | 0.703 |
| ARRDC5 | NEDD4 | ENSP00000371200 | ENSP00000424827 | Arrestin domain containing 5; Belongs to the arrestin family | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates ’Lys-63’ in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | 0.629 |
| ARRDC5 | NEDD4L | ENSP00000371200 | ENSP00000383199 | Arrestin domain containing 5; Belongs to the arrestin family | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiqu [...] | 0.586 |
| ARRDC5 | NT5C1B | ENSP00000371200 | ENSP00000352904 | Arrestin domain containing 5; Belongs to the arrestin family | Cytosolic 5’-nucleotidase 1B; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity); 5’-nucleotidases | 0.650 |
| ARRDC5 | PTPN11 | ENSP00000371200 | ENSP00000340944 | Arrestin domain containing 5; Belongs to the arrestin family | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.559 |
| ARRDC5 | PTPN6 | ENSP00000371200 | ENSP00000391592 | Arrestin domain containing 5; Belongs to the arrestin family | Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis; Protein tyrosine phosphatases, non-receptor type | 0.597 |
| ARRDC5 | VPS26A | ENSP00000371200 | ENSP00000362480 | Arrestin domain containing 5; Belongs to the arrestin family | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.620 |
| ARRDC5 | VPS26B | ENSP00000371200 | ENSP00000281187 | Arrestin domain containing 5; Belongs to the arrestin family | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.581 |
| C4orf17 | ARRDC5 | ENSP00000322582 | ENSP00000371200 | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17 | Arrestin domain containing 5; Belongs to the arrestin family | 0.796 |
| C4orf17 | LKAAEAR1 | ENSP00000322582 | ENSP00000310801 | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17 | Protein LKAAEAR1; LKAAEAR motif containing 1 | 0.793 |
| C4orf17 | NT5C1B | ENSP00000322582 | ENSP00000352904 | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17 | Cytosolic 5’-nucleotidase 1B; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity); 5’-nucleotidases | 0.727 |
| DSCR3 | ARRDC5 | ENSP00000311399 | ENSP00000371200 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Arrestin domain containing 5; Belongs to the arrestin family | 0.578 |
| DSCR3 | VPS26A | ENSP00000311399 | ENSP00000362480 | Down syndrome critical region gene 3; Belongs to the VPS26 family | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.405 |
| LKAAEAR1 | ARRDC5 | ENSP00000310801 | ENSP00000371200 | Protein LKAAEAR1; LKAAEAR motif containing 1 | Arrestin domain containing 5; Belongs to the arrestin family | 0.703 |
| LKAAEAR1 | C4orf17 | ENSP00000310801 | ENSP00000322582 | Protein LKAAEAR1; LKAAEAR motif containing 1 | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17 | 0.793 |
| LKAAEAR1 | NT5C1B | ENSP00000310801 | ENSP00000352904 | Protein LKAAEAR1; LKAAEAR motif containing 1 | Cytosolic 5’-nucleotidase 1B; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity); 5’-nucleotidases | 0.671 |
| NEDD4 | ARRDC5 | ENSP00000424827 | ENSP00000371200 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates ’Lys-63’ in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | Arrestin domain containing 5; Belongs to the arrestin family | 0.629 |
| NEDD4 | NEDD4L | ENSP00000424827 | ENSP00000383199 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates ’Lys-63’ in target proteins. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. [...] | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiqu [...] | 0.903 |
