• Version:
  • 11.0 [archived version]
STRINGSTRING
NMT1 NMT1 PPP2R3B PPP2R3B SHOX SHOX PLCXD1 PLCXD1 SERINC5 SERINC5 ASMTL ASMTL GTPBP6 GTPBP6 DHRSX DHRSX SPRY3 SPRY3 AKAP17A AKAP17A P2RY8 P2RY8
"PLCXD1" - PI-PLC X domain-containing protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCXD1PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1; Pseudoautosomal region 1 (323 aa)    
Predicted Functional Partners:
GTPBP6
Putative GTP-binding protein 6; Pseudoautosomal region 1 (516 aa)
     
   
  0.775
PPP2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B’’ subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; EF-hand domain containing (575 aa)
     
   
  0.710
DHRSX
Dehydrogenase/reductase SDR family member on chromosome X; Involved in the positive regulation of starvation- induced autophagy; Belongs to the short-chain dehydrogenases/reductases (SDR) family (330 aa)
           
  0.649
SHOX
Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily (292 aa)
           
  0.620
SERINC5
Serine incorporator 5; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity) (461 aa)
           
  0.614
ASMTL
N-acetylserotonin O-methyltransferase-like protein; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity; In the N-terminal section; belongs to the maf family (621 aa)
           
  0.591
SPRY3
Protein sprouty homolog 3; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Pseudoautosomal region 2 (288 aa)
           
  0.531
NMT1
Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (496 aa)
       
      0.527
P2RY8
P2Y purinoceptor 8; Probable receptor for purines coupled to G-proteins; G protein-coupled receptors, Class A orphans (359 aa)
           
  0.504
AKAP17A
A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner; A-kinase anchoring proteins (695 aa)
           
  0.494
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]