INSL6 protein (human) - STRING database

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INSL6

Insulin-like peptide INSL6; May have a role in sperm development and fertilization (213 aa)

Predicted Functional Partners:

INSL4

0.868

INSL5

0.860

RLN3

0.816

BORA

0.747

INSL3

0.745

RXFP4

0.733

RXFP3

0.732

RXFP1

0.684

WBP5

0.672

RMND5A

0.672

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BORA	INSL4	ENSP00000479266	ENSP00000239316	Protein aurora borealis; Required for the activation of AURKA at the onset of mitosis	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	0.400
BORA	INSL6	ENSP00000479266	ENSP00000371054	Protein aurora borealis; Required for the activation of AURKA at the onset of mitosis	Insulin-like peptide INSL6; May have a role in sperm development and fertilization	0.747
INSL3	INSL4	ENSP00000369017	ENSP00000239316	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	0.745
INSL3	INSL5	ENSP00000369017	ENSP00000302724	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	0.792
INSL3	INSL6	ENSP00000369017	ENSP00000371054	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Insulin-like peptide INSL6; May have a role in sperm development and fertilization	0.745
INSL3	RLN3	ENSP00000369017	ENSP00000397415	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin-3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family	0.978
INSL3	RXFP1	ENSP00000369017	ENSP00000405841	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors	0.983
INSL3	RXFP3	ENSP00000369017	ENSP00000328708	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors	0.733
INSL3	RXFP4	ENSP00000369017	ENSP00000357301	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to the G-protein coupled receptor 1 family	0.709
INSL4	BORA	ENSP00000239316	ENSP00000479266	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Protein aurora borealis; Required for the activation of AURKA at the onset of mitosis	0.400
INSL4	INSL3	ENSP00000239316	ENSP00000369017	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	0.745
INSL4	INSL5	ENSP00000239316	ENSP00000302724	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	0.789
INSL4	INSL6	ENSP00000239316	ENSP00000371054	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Insulin-like peptide INSL6; May have a role in sperm development and fertilization	0.868
INSL4	RLN3	ENSP00000239316	ENSP00000397415	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin-3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family	0.734
INSL4	RXFP1	ENSP00000239316	ENSP00000405841	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP; Relaxin family peptide receptors	0.669
INSL4	RXFP3	ENSP00000239316	ENSP00000328708	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors	0.649
INSL4	RXFP4	ENSP00000239316	ENSP00000357301	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to the G-protein coupled receptor 1 family	0.669
INSL5	INSL3	ENSP00000302724	ENSP00000369017	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family	0.792
INSL5	INSL4	ENSP00000302724	ENSP00000239316	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family	0.789
INSL5	INSL6	ENSP00000302724	ENSP00000371054	Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor; Belongs to the insulin family	Insulin-like peptide INSL6; May have a role in sperm development and fertilization	0.860

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