• Version:
  • 11.0 [archived version]
STRINGSTRING
NSFL1C NSFL1C PAFAH1B2 PAFAH1B2 ZNF687 ZNF687 FAM162B FAM162B SIRPD SIRPD KIAA1841 KIAA1841 C2orf74 C2orf74 ZUFSP ZUFSP TLR8 TLR8 FAM188B FAM188B CEACAM4 CEACAM4
"SIRPD" - Signal regulatory protein delta in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIRPDSignal regulatory protein delta (197 aa)    
Predicted Functional Partners:
C2orf74
Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74 (194 aa)
           
  0.589
FAM162B
Protein FAM162B; Family with sequence similarity 162 member B (162 aa)
           
  0.589
KIAA1841
Uncharacterized protein KIAA1841; KIAA1841 (718 aa)
           
  0.585
ZUFSP
Zinc finger with UFM1-specific peptidase domain (578 aa)
           
  0.583
ZNF687
Zinc finger protein 687; May be involved in transcriptional regulation (1237 aa)
           
  0.542
FAM188B
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove ’Lys-48’-linked conjugated ubiquitin from proteins (757 aa)
           
  0.539
NSFL1C
NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family (372 aa)
           
  0.471
CEACAM4
Carcinoembryonic antigen-related cell adhesion molecule 4; Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles; Carcinoembryonic antigen related cell adhesion molecule family (244 aa)
     
        0.469
PAFAH1B2
Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit (229 aa)
           
  0.445
TLR8
Toll-like receptor 8; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response; CD molecules (1059 aa)
     
        0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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