| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARSE | CD99 | ENSP00000441417 | ENSP00000370588 | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity); Blood group antigens | 0.588 |
| ARSE | CLCN4 | ENSP00000441417 | ENSP00000370213 | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons; Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily | 0.637 |
| ARSE | SHOX | ENSP00000441417 | ENSP00000370990 | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.757 |
| CD99 | ARSE | ENSP00000370588 | ENSP00000441417 | CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity); Blood group antigens | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | 0.588 |
| CD99 | SHOX | ENSP00000370588 | ENSP00000370990 | CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity); Blood group antigens | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.711 |
| CLCN4 | ARSE | ENSP00000370213 | ENSP00000441417 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons; Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | 0.637 |
| CLCN4 | SHOX | ENSP00000370213 | ENSP00000370990 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons; Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.641 |
| FGFR3 | SHOX | ENSP00000339824 | ENSP00000370990 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.660 |
| FGFR3 | SOX6 | ENSP00000339824 | ENSP00000379644 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation; SRY-boxes | 0.439 |
| GTPBP6 | PLCXD1 | ENSP00000316598 | ENSP00000371073 | Putative GTP-binding protein 6; Pseudoautosomal region 1 | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1; Pseudoautosomal region 1 | 0.775 |
| GTPBP6 | SHOX | ENSP00000316598 | ENSP00000370990 | Putative GTP-binding protein 6; Pseudoautosomal region 1 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.603 |
| LEUTX | SHOX | ENSP00000380053 | ENSP00000370990 | PRD class homeoboxes and pseudogenes | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.648 |
| NKX2-5 | SHOX | ENSP00000327758 | ENSP00000370990 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development; NKL subclass homeoboxes and pseudogenes | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.602 |
| NKX2-5 | SOX5 | ENSP00000327758 | ENSP00000398273 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development; NKL subclass homeoboxes and pseudogenes | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.705 |
| NKX2-5 | SOX6 | ENSP00000327758 | ENSP00000379644 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development; NKL subclass homeoboxes and pseudogenes | Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation; SRY-boxes | 0.559 |
| PLCXD1 | GTPBP6 | ENSP00000371073 | ENSP00000316598 | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1; Pseudoautosomal region 1 | Putative GTP-binding protein 6; Pseudoautosomal region 1 | 0.775 |
| PLCXD1 | SHOX | ENSP00000371073 | ENSP00000370990 | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1; Pseudoautosomal region 1 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.620 |
| SHOX | ARSE | ENSP00000370990 | ENSP00000441417 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases | 0.757 |
| SHOX | CD99 | ENSP00000370990 | ENSP00000370588 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity); Blood group antigens | 0.711 |
| SHOX | CLCN4 | ENSP00000370990 | ENSP00000370213 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons; Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily | 0.641 |
