LZTS1 protein (human) - STRING database

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LZTS1

Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family (596 aa)

Predicted Functional Partners:

ALMS1

0.818

EIF4ENIF1

0.818

FAM214B

0.818

DNAJC6

0.818

UNC119

0.818

SASH1

0.808

SIPA1L1

0.804

FEZ2

0.752

CDC25C

0.736

RNF6

0.716

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALMS1	DNAJC6	ENSP00000482968	ENSP00000360108	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	0.819
ALMS1	EIF4ENIF1	ENSP00000482968	ENSP00000380659	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	0.818
ALMS1	FAM214B	ENSP00000482968	ENSP00000367823	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family	0.631
ALMS1	LZTS1	ENSP00000482968	ENSP00000370981	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family	0.818
ALMS1	SASH1	ENSP00000482968	ENSP00000356437	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	SAM and SH3 domain-containing protein 1; May have a role in a signaling pathway. Could act as a tumor suppressor; SAM and SH3 domain containing	0.568
CDC25C	LZTS1	ENSP00000321656	ENSP00000370981	M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity	Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family	0.736
DNAJC6	ALMS1	ENSP00000360108	ENSP00000482968	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	0.819
DNAJC6	EIF4ENIF1	ENSP00000360108	ENSP00000380659	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	0.818
DNAJC6	FAM214B	ENSP00000360108	ENSP00000367823	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family	0.568
DNAJC6	LZTS1	ENSP00000360108	ENSP00000370981	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family	0.818
DNAJC6	SASH1	ENSP00000360108	ENSP00000356437	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	SAM and SH3 domain-containing protein 1; May have a role in a signaling pathway. Could act as a tumor suppressor; SAM and SH3 domain containing	0.577
EIF4ENIF1	ALMS1	ENSP00000380659	ENSP00000482968	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	0.818
EIF4ENIF1	DNAJC6	ENSP00000380659	ENSP00000360108	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	0.818
EIF4ENIF1	FAM214B	ENSP00000380659	ENSP00000367823	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family	0.818
EIF4ENIF1	LZTS1	ENSP00000380659	ENSP00000370981	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family	0.818
EIF4ENIF1	SASH1	ENSP00000380659	ENSP00000356437	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	SAM and SH3 domain-containing protein 1; May have a role in a signaling pathway. Could act as a tumor suppressor; SAM and SH3 domain containing	0.559
FAM214B	ALMS1	ENSP00000367823	ENSP00000482968	Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family	Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells	0.631
FAM214B	DNAJC6	ENSP00000367823	ENSP00000360108	Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family	Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity); C2 tensin-type domain containing	0.568
FAM214B	EIF4ENIF1	ENSP00000367823	ENSP00000380659	Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family	Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism	0.818
FAM214B	LZTS1	ENSP00000367823	ENSP00000370981	Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family	Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor; Leucine zipper tumor suppressor family	0.818

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