• Version:
  • 11.0 [archived version]
STRINGSTRING
GAD2 GAD2 CSAD CSAD OPLAH OPLAH GAD1 GAD1 GGT6 GGT6 GCLC GCLC LAP3 LAP3 GSR GSR GSS GSS ANPEP ANPEP GPX4 GPX4
"GGT6" - Glutathione hydrolase 6 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GGT6Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases (499 aa)    
Predicted Functional Partners:
ANPEP
Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases (967 aa)
     
 
  0.952
GSS
Glutathione synthetase; Belongs to the eukaryotic GSH synthase family (474 aa)
     
 
  0.949
OPLAH
5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate (1288 aa)
   
 
  0.937
GCLC
Glutamate-cysteine ligase catalytic subunit (637 aa)
     
 
  0.933
LAP3
Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides; Belongs to the peptidase M17 family (519 aa)
     
 
  0.928
GSR
Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol (522 aa)
       
  0.925
GAD2
Glutamate decarboxylase 2; Catalyzes the production of GABA (585 aa)
     
 
  0.914
GAD1
Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family (594 aa)
     
 
  0.913
GPX4
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-depende [...] (197 aa)
     
 
  0.911
CSAD
Cysteine sulfinic acid decarboxylase (520 aa)
     
 
  0.911
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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