node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANAPC15 | CDC20B | ENSP00000439403 | ENSP00000370781 | Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C- not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | 0.762 |
ANAPC15 | CDC6 | ENSP00000439403 | ENSP00000209728 | Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C- not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.924 |
ANAPC15 | MAD2L1 | ENSP00000439403 | ENSP00000296509 | Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C- not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate | 0.978 |
BOLL | CDC20B | ENSP00000314792 | ENSP00000370781 | Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (By similarity); Belongs to the RRM DAZ family | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | 0.870 |
BOLL | CDC25A | ENSP00000314792 | ENSP00000303706 | Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (By similarity); Belongs to the RRM DAZ family | M-phase inducer phosphatase 1; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro; Class III Cys-based CDC25 phosphatases | 0.816 |
BOLL | UBA5 | ENSP00000314792 | ENSP00000348565 | Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (By similarity); Belongs to the RRM DAZ family | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2; Ubiquitin like modifier activating enzymes | 0.865 |
CCNO | CDC20B | ENSP00000282572 | ENSP00000370781 | Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking; Belongs to the cyclin family | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | 0.786 |
CCNO | CDC6 | ENSP00000282572 | ENSP00000209728 | Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking; Belongs to the cyclin family | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.555 |
CCNO | GMNC | ENSP00000282572 | ENSP00000406164 | Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking; Belongs to the cyclin family | Geminin coiled-coil domain-containing protein 1; Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2- dependent recruitment of CDC45L onto replication origins (By similarity) | 0.672 |
CCNO | MCM5 | ENSP00000282572 | ENSP00000216122 | Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking; Belongs to the cyclin family | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.437 |
CDC20B | ANAPC15 | ENSP00000370781 | ENSP00000439403 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C- not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 | 0.762 |
CDC20B | BOLL | ENSP00000370781 | ENSP00000314792 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (By similarity); Belongs to the RRM DAZ family | 0.870 |
CDC20B | CCNO | ENSP00000370781 | ENSP00000282572 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking; Belongs to the cyclin family | 0.786 |
CDC20B | CDC25A | ENSP00000370781 | ENSP00000303706 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | M-phase inducer phosphatase 1; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro; Class III Cys-based CDC25 phosphatases | 0.792 |
CDC20B | CDC6 | ENSP00000370781 | ENSP00000209728 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.688 |
CDC20B | CDK6 | ENSP00000370781 | ENSP00000265734 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...] | 0.819 |
CDC20B | GMNC | ENSP00000370781 | ENSP00000406164 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Geminin coiled-coil domain-containing protein 1; Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2- dependent recruitment of CDC45L onto replication origins (By similarity) | 0.666 |
CDC20B | MAD2L1 | ENSP00000370781 | ENSP00000296509 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate | 0.703 |
CDC20B | MCM5 | ENSP00000370781 | ENSP00000216122 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.681 |
CDC20B | UBA5 | ENSP00000370781 | ENSP00000348565 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2; Ubiquitin like modifier activating enzymes | 0.813 |