node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | ALPL | ENSP00000295463 | ENSP00000363973 | Alkaline phosphatase, intestinal | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | 0.905 |
ALPI | CEACAM5 | ENSP00000295463 | ENSP00000221992 | Alkaline phosphatase, intestinal | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | 0.916 |
ALPI | GP2 | ENSP00000295463 | ENSP00000370767 | Alkaline phosphatase, intestinal | Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2 | 0.904 |
ALPI | LYPD8 | ENSP00000295463 | ENSP00000466070 | Alkaline phosphatase, intestinal | Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis; LY6/PLAUR domain containing | 0.907 |
ALPI | MSLN | ENSP00000295463 | ENSP00000372313 | Alkaline phosphatase, intestinal | Mesothelin; Membrane-anchored forms may play a role in cellular adhesion | 0.903 |
ALPI | NEGR1 | ENSP00000295463 | ENSP00000350364 | Alkaline phosphatase, intestinal | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity); Belongs to the immunoglobulin superfamily. IgLON family | 0.902 |
ALPI | SPACA4 | ENSP00000295463 | ENSP00000312774 | Alkaline phosphatase, intestinal | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing | 0.902 |
ALPI | TECTA | ENSP00000295463 | ENSP00000376543 | Alkaline phosphatase, intestinal | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals; Deafness associated genes | 0.906 |
ALPI | VNN1 | ENSP00000295463 | ENSP00000356905 | Alkaline phosphatase, intestinal | Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family | 0.901 |
ALPL | ALPI | ENSP00000363973 | ENSP00000295463 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Alkaline phosphatase, intestinal | 0.905 |
ALPL | CEACAM5 | ENSP00000363973 | ENSP00000221992 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | 0.908 |
ALPL | GP2 | ENSP00000363973 | ENSP00000370767 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2 | 0.905 |
ALPL | LYPD8 | ENSP00000363973 | ENSP00000466070 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis; LY6/PLAUR domain containing | 0.902 |
ALPL | MSLN | ENSP00000363973 | ENSP00000372313 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Mesothelin; Membrane-anchored forms may play a role in cellular adhesion | 0.900 |
ALPL | NEGR1 | ENSP00000363973 | ENSP00000350364 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity); Belongs to the immunoglobulin superfamily. IgLON family | 0.902 |
ALPL | SPACA4 | ENSP00000363973 | ENSP00000312774 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing | 0.900 |
ALPL | TECTA | ENSP00000363973 | ENSP00000376543 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals; Deafness associated genes | 0.906 |
ALPL | VNN1 | ENSP00000363973 | ENSP00000356905 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family | 0.905 |
CEACAM5 | ALPI | ENSP00000221992 | ENSP00000295463 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | Alkaline phosphatase, intestinal | 0.916 |
CEACAM5 | ALPL | ENSP00000221992 | ENSP00000363973 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family | 0.908 |