ARSF protein (human) - STRING database

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ARSF

Arylsulfatase F; Sulfatases (590 aa)

Predicted Functional Partners:

SUMF1

0.970

SUMF2

0.947

ARSB

0.934

ARSA

0.919

ARSK

0.918

ARSJ

0.916

ARSI

0.916

ARSD

0.915

STS

0.912

ARSG

0.909

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSA	ARSB	ENSP00000216124	ENSP00000264914	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	0.936
ARSA	ARSD	ENSP00000216124	ENSP00000370546	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase D; Sulfatases	0.922
ARSA	ARSF	ENSP00000216124	ENSP00000370519	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase F; Sulfatases	0.919
ARSA	ARSG	ENSP00000216124	ENSP00000407193	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate; Sulfatases	0.921
ARSA	ARSI	ENSP00000216124	ENSP00000333395	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts; Sulfatases	0.920
ARSA	ARSJ	ENSP00000216124	ENSP00000320219	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase family member J; Sulfatases	0.920
ARSA	ARSK	ENSP00000216124	ENSP00000369346	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Arylsulfatase family member K; Sulfatases	0.925
ARSA	STS	ENSP00000216124	ENSP00000217961	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases	0.917
ARSA	SUMF1	ENSP00000216124	ENSP00000272902	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family	0.980
ARSA	SUMF2	ENSP00000216124	ENSP00000341938	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Sulfatase-modifying factor 2; Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1	0.957
ARSB	ARSA	ENSP00000264914	ENSP00000216124	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	0.936
ARSB	ARSD	ENSP00000264914	ENSP00000370546	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase D; Sulfatases	0.937
ARSB	ARSF	ENSP00000264914	ENSP00000370519	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase F; Sulfatases	0.934
ARSB	ARSG	ENSP00000264914	ENSP00000407193	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate; Sulfatases	0.923
ARSB	ARSI	ENSP00000264914	ENSP00000333395	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts; Sulfatases	0.903
ARSB	ARSJ	ENSP00000264914	ENSP00000320219	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase family member J; Sulfatases	0.903
ARSB	ARSK	ENSP00000264914	ENSP00000369346	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Arylsulfatase family member K; Sulfatases	0.949
ARSB	STS	ENSP00000264914	ENSP00000217961	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases	0.934
ARSB	SUMF1	ENSP00000264914	ENSP00000272902	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family	0.976
ARSB	SUMF2	ENSP00000264914	ENSP00000341938	Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family	Sulfatase-modifying factor 2; Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1	0.951

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