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  • 11.0 [archived version]
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OFCC1 OFCC1 TUSC1 TUSC1 TYRP1 TYRP1 SRSF2 SRSF2 WDR6 WDR6 BNC2 BNC2 CNTLN CNTLN DALRD3 DALRD3 SH3GL2 SH3GL2 LMBRD2 LMBRD2 MYO15A MYO15A
"BNC2" - Zinc finger protein basonuclin-2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
BNC2Zinc finger protein basonuclin-2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes; Zinc fingers C2H2-type (1099 aa)    
Predicted Functional Partners:
SRSF2
Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5’- and 3’-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5’-AGSAGAGTA-3’ (S=C or G) or [...] (221 aa)
           
  0.756
TUSC1
Tumor suppressor candidate 1 (212 aa)
           
  0.688
CNTLN
Centlein; Required for centrosome cohesion and recruitment of CEP68 to centrosomes (1406 aa)
           
  0.661
SH3GL2
Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes; N-BAR domain containing (352 aa)
           
  0.645
DALRD3
DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3 (543 aa)
           
  0.630
WDR6
WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy; WD repeat domain containing (1151 aa)
           
  0.609
TYRP1
5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity) (537 aa)
           
  0.589
OFCC1
Orofacial cleft 1 candidate 1 (300 aa)
           
  0.563
MYO15A
Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (3530 aa)
           
  0.542
LMBRD2
LMBR1 domain containing 2 (695 aa)
           
  0.533
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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