HADHA protein (human) - STRING database

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HADHA

Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family (763 aa)

Predicted Functional Partners:

HADHB

0.999

ACAT1

0.986

ACAA2

0.985

ACADVL

0.979

ACADM

0.978

ACAA1

0.977

ACAT2

0.973

ACADS

0.972

ACADL

0.964

ACOX1

0.961

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	ACAA2	ENSP00000333664	ENSP00000285093	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.843
ACAA1	ACADL	ENSP00000333664	ENSP00000233710	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Long-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-CoA dehydrogenase long chain; Belongs to the acyl-CoA dehydrogenase family	0.950
ACAA1	ACADM	ENSP00000333664	ENSP00000359871	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)	0.975
ACAA1	ACADS	ENSP00000333664	ENSP00000242592	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	0.980
ACAA1	ACADVL	ENSP00000333664	ENSP00000438689	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons; Belongs to the acyl-CoA dehydrogenase family	0.976
ACAA1	ACAT1	ENSP00000333664	ENSP00000265838	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.932
ACAA1	ACAT2	ENSP00000333664	ENSP00000356015	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.919
ACAA1	ACOX1	ENSP00000333664	ENSP00000293217	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA	0.991
ACAA1	HADHA	ENSP00000333664	ENSP00000370023	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.977
ACAA1	HADHB	ENSP00000333664	ENSP00000325136	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.842
ACAA2	ACAA1	ENSP00000285093	ENSP00000333664	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1	0.843
ACAA2	ACADL	ENSP00000285093	ENSP00000233710	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Long-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-CoA dehydrogenase long chain; Belongs to the acyl-CoA dehydrogenase family	0.964
ACAA2	ACADM	ENSP00000285093	ENSP00000359871	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)	0.996
ACAA2	ACADS	ENSP00000285093	ENSP00000242592	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA’s of short chain length, i.e. less than 6 carbon atoms; Belongs to the acyl-CoA dehydrogenase family	0.984
ACAA2	ACADVL	ENSP00000285093	ENSP00000438689	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons; Belongs to the acyl-CoA dehydrogenase family	0.979
ACAA2	ACAT1	ENSP00000285093	ENSP00000265838	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism	0.964
ACAA2	ACAT2	ENSP00000285093	ENSP00000356015	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2	0.915
ACAA2	ACOX1	ENSP00000285093	ENSP00000293217	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA	0.960
ACAA2	HADHA	ENSP00000285093	ENSP00000370023	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family	0.985
ACAA2	HADHB	ENSP00000285093	ENSP00000325136	3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	0.925

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