node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CELSR2 | EGFL6 | ENSP00000271332 | ENSP00000369976 | Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | 0.582 |
CTPS2 | EGFL6 | ENSP00000401264 | ENSP00000369976 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | 0.574 |
EGFL6 | CELSR2 | ENSP00000369976 | ENSP00000271332 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.582 |
EGFL6 | CTPS2 | ENSP00000369976 | ENSP00000401264 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | 0.574 |
EGFL6 | FAM196B | ENSP00000369976 | ENSP00000366582 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | 0.692 |
EGFL6 | FREM2 | ENSP00000369976 | ENSP00000280481 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | 0.491 |
EGFL6 | LGI3 | ENSP00000369976 | ENSP00000302297 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | 0.499 |
EGFL6 | LRRC34 | ENSP00000369976 | ENSP00000414635 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | 0.663 |
EGFL6 | LYPD6 | ENSP00000369976 | ENSP00000334463 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity); LY6/PLAUR domain containing | 0.526 |
EGFL6 | MEGF9 | ENSP00000369976 | ENSP00000363040 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | Multiple epidermal growth factor-like domains protein 9; Multiple EGF like domains 9 | 0.677 |
EGFL6 | SYVN1 | ENSP00000369976 | ENSP00000366395 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | E3 ubiquitin-protein ligase synoviolin; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from [...] | 0.798 |
EGFL6 | TMEM174 | ENSP00000369976 | ENSP00000296776 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | Transmembrane protein 174 | 0.685 |
FAM196B | EGFL6 | ENSP00000366582 | ENSP00000369976 | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | 0.692 |
FAM196B | LRRC34 | ENSP00000366582 | ENSP00000414635 | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | 0.744 |
FAM196B | LYPD6 | ENSP00000366582 | ENSP00000334463 | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity); LY6/PLAUR domain containing | 0.666 |
FAM196B | TMEM174 | ENSP00000366582 | ENSP00000296776 | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | Transmembrane protein 174 | 0.800 |
FREM2 | EGFL6 | ENSP00000280481 | ENSP00000369976 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | 0.491 |
LGI3 | EGFL6 | ENSP00000302297 | ENSP00000369976 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | 0.499 |
LRRC34 | EGFL6 | ENSP00000414635 | ENSP00000369976 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin family | 0.663 |
LRRC34 | FAM196B | ENSP00000414635 | ENSP00000366582 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family | 0.744 |