| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKS1A | FAM154A | ENSP00000353518 | ENSP00000369907 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.527 |
| FAM154A | ANKS1A | ENSP00000369907 | ENSP00000353518 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity); Ankyrin repeat domain containing | 0.527 |
| FAM154A | GAREM | ENSP00000369907 | ENSP00000269209 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | 0.587 |
| FAM154A | GPR133 | ENSP00000369907 | ENSP00000261654 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | Adhesion G-protein coupled receptor D1; Orphan receptor. Signals via G(s)-alpha family of G- proteins. Has protumorigenic function especially in glioblastoma | 0.530 |
| FAM154A | MICAL3 | ENSP00000369907 | ENSP00000416015 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | [F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion- the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required fo [...] | 0.491 |
| FAM154A | NINL | ENSP00000369907 | ENSP00000278886 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing | 0.475 |
| FAM154A | OARD1 | ENSP00000369907 | ENSP00000420484 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | O-acetyl-ADP-ribose deacetylase 1; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O- acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP- ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively | 0.543 |
| FAM154A | SLC35D2 | ENSP00000369907 | ENSP00000253270 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling; Solute carriers | 0.561 |
| FAM154A | TEX38 | ENSP00000369907 | ENSP00000455854 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | Testis-expressed protein 38; Testis expressed 38 | 0.526 |
| FAM154A | THSD7B | ENSP00000369907 | ENSP00000272643 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B | 0.571 |
| FAM154A | TSSC4 | ENSP00000369907 | ENSP00000331087 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | Protein TSSC4; Tumor suppressing subtransferable candidate 4 | 0.541 |
| GAREM | FAM154A | ENSP00000269209 | ENSP00000369907 | GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.587 |
| GPR133 | FAM154A | ENSP00000261654 | ENSP00000369907 | Adhesion G-protein coupled receptor D1; Orphan receptor. Signals via G(s)-alpha family of G- proteins. Has protumorigenic function especially in glioblastoma | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.530 |
| MICAL3 | FAM154A | ENSP00000416015 | ENSP00000369907 | [F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion- the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required fo [...] | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.491 |
| MICAL3 | NINL | ENSP00000416015 | ENSP00000278886 | [F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion- the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required fo [...] | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing | 0.577 |
| MICAL3 | THSD7B | ENSP00000416015 | ENSP00000272643 | [F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion- the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required fo [...] | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B | 0.407 |
| NINL | FAM154A | ENSP00000278886 | ENSP00000369907 | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.475 |
| NINL | MICAL3 | ENSP00000278886 | ENSP00000416015 | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis; EF-hand domain containing | [F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion- the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required fo [...] | 0.577 |
| OARD1 | FAM154A | ENSP00000420484 | ENSP00000369907 | O-acetyl-ADP-ribose deacetylase 1; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O- acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP- ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.543 |
| SLC35D2 | FAM154A | ENSP00000253270 | ENSP00000369907 | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling; Solute carriers | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family | 0.561 |
