node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000197054 | OTUD7A | ENSP00000369774 | ENSP00000305926 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | 0.719 |
ENSG00000197054 | RABGEF1 | ENSP00000369774 | ENSP00000370208 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | RAB guanine nucleotide exchange factor 1; VPS9 domain containing | 0.545 |
ENSG00000197054 | SETDB1 | ENSP00000369774 | ENSP00000271640 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] | 0.533 |
ENSG00000197054 | TRIM28 | ENSP00000369774 | ENSP00000253024 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.627 |
ENSG00000197054 | UBA2 | ENSP00000369774 | ENSP00000246548 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.543 |
ENSG00000197054 | UBC | ENSP00000369774 | ENSP00000441543 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | 0.583 |
ENSG00000197054 | UBD | ENSP00000369774 | ENSP00000366249 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear tr [...] | 0.566 |
ENSG00000197054 | USP44 | ENSP00000369774 | ENSP00000258499 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...] | 0.716 |
ENSG00000197054 | USP5 | ENSP00000369774 | ENSP00000229268 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored ’Lys-48’-linked polyubiquitin disassembly. Binds linear and ’Lys- 63’-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition; Ubiquitin specific peptidases | 0.653 |
ENSG00000197054 | YOD1 | ENSP00000369774 | ENSP00000326813 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] | 0.718 |
OTUD7A | ENSG00000197054 | ENSP00000305926 | ENSP00000369774 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.719 |
OTUD7A | UBC | ENSP00000305926 | ENSP00000441543 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | 0.957 |
OTUD7A | UBD | ENSP00000305926 | ENSP00000366249 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear tr [...] | 0.461 |
OTUD7A | YOD1 | ENSP00000305926 | ENSP00000326813 | OTU domain-containing protein 7A; Has deubiquitinating activity towards ’Lys-11’-linked polyubiquitin chains; Belongs to the peptidase C64 family | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] | 0.560 |
RABGEF1 | ENSG00000197054 | ENSP00000370208 | ENSP00000369774 | RAB guanine nucleotide exchange factor 1; VPS9 domain containing | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.545 |
RABGEF1 | UBC | ENSP00000370208 | ENSP00000441543 | RAB guanine nucleotide exchange factor 1; VPS9 domain containing | Polyubiquitin-C; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | 0.977 |
RABGEF1 | UBD | ENSP00000370208 | ENSP00000366249 | RAB guanine nucleotide exchange factor 1; VPS9 domain containing | Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear tr [...] | 0.824 |
SETDB1 | ENSG00000197054 | ENSP00000271640 | ENSP00000369774 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.533 |
SETDB1 | TRIM28 | ENSP00000271640 | ENSP00000253024 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates ’Lys-9’ of histone H3. H3 ’Lys-9’ trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 ’Lys-9’ trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ’Lys-9’ t [...] | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.852 |
TRIM28 | ENSG00000197054 | ENSP00000253024 | ENSP00000369774 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.627 |