| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHSA2 | LHFPL2 | ENSP00000377970 | ENSP00000369702 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | 0.534 |
| ALG5 | LHFPL2 | ENSP00000239891 | ENSP00000369702 | ALG5, dolichyl-phosphate beta-glucosyltransferase; Glycosyltransferase family 2 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | 0.660 |
| ASF1A | BIN3 | ENSP00000229595 | ENSP00000276416 | Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; Belongs to the ASF1 family | Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin; N-BAR domain containing | 0.467 |
| ASF1A | LHFPL2 | ENSP00000229595 | ENSP00000369702 | Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; Belongs to the ASF1 family | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | 0.548 |
| BIN3 | ASF1A | ENSP00000276416 | ENSP00000229595 | Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin; N-BAR domain containing | Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; Belongs to the ASF1 family | 0.467 |
| BIN3 | LHFPL2 | ENSP00000276416 | ENSP00000369702 | Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin; N-BAR domain containing | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | 0.568 |
| FBLN5 | LHFPL2 | ENSP00000345008 | ENSP00000369702 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN; Belongs to the fibulin family | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | 0.603 |
| JADE1 | LHFPL2 | ENSP00000226319 | ENSP00000369702 | Protein Jade-1; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function; PHD finger proteins | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | 0.525 |
| JADE1 | SLC37A1 | ENSP00000226319 | ENSP00000344648 | Protein Jade-1; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function; PHD finger proteins | Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6- phosphatase. May not play a role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family | 0.516 |
| JADE1 | TMEM51 | ENSP00000226319 | ENSP00000394899 | Protein Jade-1; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function; PHD finger proteins | Transmembrane protein 51 | 0.531 |
| JADE1 | TMEM86A | ENSP00000226319 | ENSP00000280734 | Protein Jade-1; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function; PHD finger proteins | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A | 0.538 |
| JADE1 | TSPAN14 | ENSP00000226319 | ENSP00000396270 | Protein Jade-1; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function; PHD finger proteins | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10- mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity); Belongs to the tetraspanin (TM4SF) family | 0.514 |
| LHFPL2 | AHSA2 | ENSP00000369702 | ENSP00000377970 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity | 0.534 |
| LHFPL2 | ALG5 | ENSP00000369702 | ENSP00000239891 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | ALG5, dolichyl-phosphate beta-glucosyltransferase; Glycosyltransferase family 2 | 0.660 |
| LHFPL2 | ASF1A | ENSP00000369702 | ENSP00000229595 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit; Belongs to the ASF1 family | 0.548 |
| LHFPL2 | BIN3 | ENSP00000369702 | ENSP00000276416 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin; N-BAR domain containing | 0.568 |
| LHFPL2 | FBLN5 | ENSP00000369702 | ENSP00000345008 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN; Belongs to the fibulin family | 0.603 |
| LHFPL2 | JADE1 | ENSP00000369702 | ENSP00000226319 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | Protein Jade-1; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function; PHD finger proteins | 0.525 |
| LHFPL2 | SLC37A1 | ENSP00000369702 | ENSP00000344648 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6- phosphatase. May not play a role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family | 0.592 |
| LHFPL2 | TMEM51 | ENSP00000369702 | ENSP00000394899 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins | Transmembrane protein 51 | 0.618 |
